Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4633579..4634181 Replicon chromosome
Accession NZ_CP117312
Organism Salmonella enterica subsp. enterica serovar Derby strain RM003

Toxin (Protein)


Gene name higB Uniprot ID A0A3Y7R225
Locus tag PQP99_RS22505 Protein ID WP_023232499.1
Coordinates 4633870..4634181 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQP99_RS22500 Protein ID WP_000362050.1
Coordinates 4633579..4633869 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP99_RS22485 (4631072) 4631072..4631974 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
PQP99_RS22490 (4631971) 4631971..4632606 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PQP99_RS22495 (4632603) 4632603..4633532 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PQP99_RS22500 (4633579) 4633579..4633869 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQP99_RS22505 (4633870) 4633870..4634181 - 312 WP_023232499.1 hypothetical protein Toxin
PQP99_RS22510 (4634399) 4634399..4635328 + 930 WP_023232500.1 alpha/beta hydrolase -
PQP99_RS22515 (4635414) 4635414..4635725 + 312 WP_274879048.1 type II toxin-antitoxin system HigB family toxin -
PQP99_RS22520 (4635722) 4635722..4636168 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
PQP99_RS22525 (4636183) 4636183..4637124 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQP99_RS22530 (4637169) 4637169..4637606 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
PQP99_RS22535 (4637603) 4637603..4638472 - 870 WP_023203606.1 virulence factor BrkB family protein -
PQP99_RS22540 (4638466) 4638466..4639065 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12388.34 Da        Isoelectric Point: 9.4460

>T270467 WP_023232499.1 NZ_CP117312:c4634181-4633870 [Salmonella enterica subsp. enterica serovar Derby]
MQFIETELFTEDVKKLLDDDEYHKFQVFMAQHPDCGDVIQETGGLRKMRWGVRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT270467 WP_000362050.1 NZ_CP117312:c4633869-4633579 [Salmonella enterica subsp. enterica serovar Derby]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Y7R225

Antitoxin

Source ID Structure

References