Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4638214..4638816 Replicon chromosome
Accession NZ_CP117307
Organism Salmonella enterica subsp. enterica serovar Derby strain RM004

Toxin (Protein)


Gene name higB Uniprot ID A0A3Y7R225
Locus tag PQQ01_RS22545 Protein ID WP_023232499.1
Coordinates 4638505..4638816 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQQ01_RS22540 Protein ID WP_000362050.1
Coordinates 4638214..4638504 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ01_RS22525 (4635707) 4635707..4636609 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
PQQ01_RS22530 (4636606) 4636606..4637241 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PQQ01_RS22535 (4637238) 4637238..4638167 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PQQ01_RS22540 (4638214) 4638214..4638504 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQQ01_RS22545 (4638505) 4638505..4638816 - 312 WP_023232499.1 hypothetical protein Toxin
PQQ01_RS22550 (4639034) 4639034..4639963 + 930 WP_023232500.1 alpha/beta hydrolase -
PQQ01_RS22555 (4640049) 4640049..4640360 + 312 WP_000558164.1 type II toxin-antitoxin system HigB family toxin -
PQQ01_RS22560 (4640357) 4640357..4640803 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
PQQ01_RS22565 (4640818) 4640818..4641759 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQQ01_RS22570 (4641804) 4641804..4642241 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
PQQ01_RS22575 (4642238) 4642238..4643107 - 870 WP_023203606.1 virulence factor BrkB family protein -
PQQ01_RS22580 (4643101) 4643101..4643700 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12388.34 Da        Isoelectric Point: 9.4460

>T270451 WP_023232499.1 NZ_CP117307:c4638816-4638505 [Salmonella enterica subsp. enterica serovar Derby]
MQFIETELFTEDVKKLLDDDEYHKFQVFMAQHPDCGDVIQETGGLRKMRWGVRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT270451 WP_000362050.1 NZ_CP117307:c4638504-4638214 [Salmonella enterica subsp. enterica serovar Derby]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Y7R225

Antitoxin

Source ID Structure

References