Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4630633..4631235 Replicon chromosome
Accession NZ_CP117301
Organism Salmonella enterica subsp. enterica serovar Derby strain RM006

Toxin (Protein)


Gene name higB Uniprot ID A0A3Y7R225
Locus tag PQP83_RS22475 Protein ID WP_023232499.1
Coordinates 4630924..4631235 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQP83_RS22470 Protein ID WP_000362050.1
Coordinates 4630633..4630923 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP83_RS22455 (4628126) 4628126..4629028 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
PQP83_RS22460 (4629025) 4629025..4629660 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PQP83_RS22465 (4629657) 4629657..4630586 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PQP83_RS22470 (4630633) 4630633..4630923 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQP83_RS22475 (4630924) 4630924..4631235 - 312 WP_023232499.1 hypothetical protein Toxin
PQP83_RS22480 (4631453) 4631453..4632382 + 930 WP_023232500.1 alpha/beta hydrolase -
PQP83_RS22485 (4632468) 4632468..4632778 + 311 Protein_4393 type II toxin-antitoxin system HigB family toxin -
PQP83_RS22490 (4632775) 4632775..4633221 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
PQP83_RS22495 (4633236) 4633236..4634177 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQP83_RS22500 (4634222) 4634222..4634659 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
PQP83_RS22505 (4634656) 4634656..4635525 - 870 WP_023203606.1 virulence factor BrkB family protein -
PQP83_RS22510 (4635519) 4635519..4636118 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12388.34 Da        Isoelectric Point: 9.4460

>T270420 WP_023232499.1 NZ_CP117301:c4631235-4630924 [Salmonella enterica subsp. enterica serovar Derby]
MQFIETELFTEDVKKLLDDDEYHKFQVFMAQHPDCGDVIQETGGLRKMRWGVRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT270420 WP_000362050.1 NZ_CP117301:c4630923-4630633 [Salmonella enterica subsp. enterica serovar Derby]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Y7R225

Antitoxin

Source ID Structure

References