270405

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5854540..5855135 Replicon chromosome
Accession NZ_CP117300
Organism Pseudomonas aeruginosa strain 0201761-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PSH15_RS27895 Protein ID WP_071536079.1
Coordinates 5854857..5855135 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PSH15_RS27890 Protein ID WP_003099268.1
Coordinates 5854540..5854845 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSH15_RS27855 (PSH15_27855) 5849680..5850528 + 849 WP_003099284.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
PSH15_RS27865 (PSH15_27865) 5850695..5851636 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
PSH15_RS27870 (PSH15_27870) 5851753..5852367 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
PSH15_RS27875 (PSH15_27875) 5852409..5852993 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
PSH15_RS27880 (PSH15_27880) 5853034..5854134 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
PSH15_RS27890 (PSH15_27890) 5854540..5854845 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
PSH15_RS27895 (PSH15_27895) 5854857..5855135 - 279 WP_071536079.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PSH15_RS27900 (PSH15_27900) 5855188..5855316 - 129 Protein_5514 integrase -
PSH15_RS27905 (PSH15_27905) 5855464..5857692 + 2229 WP_003121052.1 TonB-dependent receptor -
PSH15_RS27910 (PSH15_27910) 5857762..5858409 - 648 WP_003095021.1 carbonate dehydratase -
PSH15_RS27915 (PSH15_27915) 5858471..5859709 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10632.17 Da        Isoelectric Point: 7.8937

>T270405 WP_071536079.1 NZ_CP117300:c5855135-5854857 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAGTELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT270405 WP_003099268.1 NZ_CP117300:c5854845-5854540 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References