Detailed information of TA system TA027038

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 581037..581690
• Replicon: chromosome
• Accession: NC_017573
• Organism: Serratia sp. AS13

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A7U3YYL4
• Locus tag: SERAS13_RS02690
• Protein ID: WP_013811355.1
• Coordinates: 581037..581387 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: SERAS13_RS02695
• Protein ID: WP_013811356.1
• Coordinates: 581391..581690 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SERAS13_RS02665	576516..577607	+	1092	WP_004949798.1	dimethyl sulfone monooxygenase SfnG	-
SERAS13_RS02670	577609..578310	-	702	WP_006323392.1	trehalose-6-phosphate synthase	-
SERAS13_RS02675	578325..578864	-	540	WP_013811352.1	GNAT family N-acetyltransferase	-
SERAS13_RS02680	578922..580301	-	1380	WP_013811353.1	glutamine synthetase family protein	-
SERAS13_RS02685	580557..580871	+	315	WP_013811354.1	hypothetical protein	-
SERAS13_RS02690	581037..581387	+	351	WP_013811355.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SERAS13_RS02695	581391..581690	+	300	WP_013811356.1	helix-turn-helix transcriptional regulator	Antitoxin
SERAS13_RS02700	581783..582859	-	1077	WP_013811357.1	YncE family protein	-
SERAS13_RS02705	583145..584413	-	1269	WP_013811358.1	multidrug effflux MFS transporter	-
SERAS13_RS02710	584413..585636	-	1224	WP_013811359.1	cytochrome P450	-
SERAS13_RS02715	585651..585908	-	258	WP_013811360.1	acyl carrier protein	-
SERAS13_RS02720	585955..586506	-	552	WP_013811361.1	NAD(P)H-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (31-83)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13456.56 Da
• Isoelectric Point: 8.5393

>T27038 WP_013811355.1 NC_017573:581037-581387 [Serratia sp. AS13]
MWTVITTEEFDRWFAVQDELTQEKVLAALVLLERSGPNLSRPFVDSLRGSQHPNMKELRVQHKGRPIRAFFAFDSLRQAI
VLCAGDKTGNEKRFYKVMLPIADAQFTQHLMCNFKE

Nucleotide

• Length: 351 bp

>T27038 NC_017573:581037-581387 [Serratia sp. AS13]
ATGTGGACTGTAATAACAACGGAAGAGTTTGATCGGTGGTTTGCGGTGCAGGATGAACTTACTCAGGAGAAAGTGCTGGC
TGCATTAGTATTGCTTGAGCGGAGTGGCCCCAACCTCTCACGTCCTTTTGTAGACTCGTTGAGAGGGTCACAGCACCCTA
ATATGAAAGAACTGCGGGTTCAGCATAAAGGGCGGCCGATTCGCGCTTTTTTTGCCTTTGACTCACTACGTCAGGCTATT
GTTTTGTGTGCCGGCGATAAGACTGGTAACGAGAAGCGGTTTTACAAAGTCATGCTGCCTATTGCGGATGCGCAGTTTAC
CCAGCATTTGATGTGTAATTTTAAGGAGTAG

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11183.85 Da
• Isoelectric Point: 5.1667

>AT27038 WP_013811356.1 NC_017573:581391-581690 [Serratia sp. AS13]
MGTLKDMLASRTPESLQRIEEMAQEMWLEARLYQLREALNISQQELANNLGISQPSVAAIEQRGNELKISTLKRYVEAMG
GTLRLDVELPDGKHVGFRV

Nucleotide

• Length: 300 bp

>AT27038 NC_017573:581391-581690 [Serratia sp. AS13]
ATGGGTACTTTAAAAGACATGCTAGCCTCGCGTACCCCGGAGAGTCTGCAACGAATCGAAGAAATGGCGCAAGAGATGTG
GCTGGAAGCACGGTTGTACCAATTGCGTGAGGCGCTGAATATCTCACAGCAGGAACTGGCGAATAATCTGGGTATCTCCC
AGCCTTCCGTCGCGGCGATAGAGCAGCGTGGCAATGAGCTGAAGATATCGACATTGAAGCGCTATGTGGAAGCGATGGGC
GGAACGTTGCGGCTGGATGTCGAACTGCCGGACGGCAAGCACGTTGGATTTAGAGTTTAA

Structures

Toxin

• AlphaFold DB: A0A7U3YYL4