Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 351800..352402 Replicon chromosome
Accession NZ_CP117299
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM-F22S

Toxin (Protein)


Gene name higB Uniprot ID A0A3V4SQH3
Locus tag PH350_RS01715 Protein ID WP_001159628.1
Coordinates 351800..352111 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PH350_RS01720 Protein ID WP_000362050.1
Coordinates 352112..352402 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PH350_RS01680 (346913) 346913..347512 + 600 WP_000965702.1 glucose-1-phosphatase -
PH350_RS01685 (347506) 347506..348378 + 873 WP_000921423.1 virulence factor BrkB family protein -
PH350_RS01690 (348375) 348375..348812 + 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
PH350_RS01695 (348857) 348857..349798 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PH350_RS01700 (349813) 349813..350259 - 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
PH350_RS01705 (350256) 350256..350567 - 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
PH350_RS01710 (350653) 350653..351582 - 930 WP_017441897.1 alpha/beta hydrolase -
PH350_RS01715 (351800) 351800..352111 + 312 WP_001159628.1 hypothetical protein Toxin
PH350_RS01720 (352112) 352112..352402 + 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PH350_RS01725 (352449) 352449..353378 - 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PH350_RS01730 (353375) 353375..354010 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PH350_RS01735 (354007) 354007..354909 - 903 WP_000331364.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12376.29 Da        Isoelectric Point: 9.4460

>T270376 WP_001159628.1 NZ_CP117299:351800-352111 [Salmonella enterica subsp. enterica serovar Mbandaka]
MQFIETELFTEDVKKLLDDDEYHKFQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT270376 WP_000362050.1 NZ_CP117299:352112-352402 [Salmonella enterica subsp. enterica serovar Mbandaka]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SQH3

Antitoxin

Source ID Structure

References