Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4201856..4202550 Replicon chromosome
Accession NC_017564
Organism Yersinia enterocolitica subsp. palearctica Y11

Toxin (Protein)


Gene name mqsR Uniprot ID A0A7U7FJ92
Locus tag Y11_RS19090 Protein ID WP_005166025.1
Coordinates 4201856..4202152 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID A0A7U7IQA2
Locus tag Y11_RS19095 Protein ID WP_005166024.1
Coordinates 4202152..4202550 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Y11_RS19065 4197329..4198427 + 1099 WP_020282590.1 peptide chain release factor 2 -
Y11_RS19070 4198437..4199954 + 1518 WP_005166031.1 lysine--tRNA ligase -
Y11_RS19080 4201011..4201271 + 261 WP_005166028.1 type II toxin-antitoxin system RelE/ParE family toxin -
Y11_RS19085 4201337..4201699 + 363 WP_005166026.1 helix-turn-helix domain-containing protein -
Y11_RS19090 4201856..4202152 + 297 WP_005166025.1 type II toxin-antitoxin system MqsR family toxin Toxin
Y11_RS19095 4202152..4202550 + 399 WP_005166024.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
Y11_RS19100 4202657..4203859 - 1203 WP_005177049.1 IS256 family transposase -
Y11_RS19105 4204008..4204208 - 201 WP_005166614.1 AlpA family transcriptional regulator -
Y11_RS19110 4204226..4205062 + 837 Protein_3726 Fic family protein -
Y11_RS19115 4205434..4205829 + 396 WP_005166615.1 SgcJ/EcaC family oxidoreductase -
Y11_RS19120 4205912..4207156 + 1245 WP_005166619.1 sensor domain-containing diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11322.18 Da        Isoelectric Point: 7.7766

>T27024 WP_005166025.1 NC_017564:4201856-4202152 [Yersinia enterocolitica subsp. palearctica Y11]
MEKRTPHTRLLKVKELVLKGNVKSTRTARDGAEELGLSFRDMCDVVCELTSADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLIVSFKEL

Download         Length: 297 bp

>T27024 NC_017564:4201856-4202152 [Yersinia enterocolitica subsp. palearctica Y11]
ATGGAGAAACGGACTCCGCATACTCGTTTACTAAAAGTAAAAGAATTGGTATTGAAAGGGAATGTTAAATCGACTCGAAC
TGCCAGAGATGGCGCTGAAGAGCTGGGGCTGAGTTTTAGGGATATGTGTGATGTAGTTTGCGAACTGACTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACGATTTGGCAGGATGTTTACCGCCCCATGCTTTCGTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGATTGTCTCGTTTAAGGAGCTTTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14716.19 Da        Isoelectric Point: 8.8165

>AT27024 WP_005166024.1 NC_017564:4202152-4202550 [Yersinia enterocolitica subsp. palearctica Y11]
MMKCPVCGGAELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETIMTEAESDTYAAKTMLLRKMVNTESIAPAYIVQVRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHRSTIKLLQVLDKYPELLNEIR

Download         Length: 399 bp

>AT27024 NC_017564:4202152-4202550 [Yersinia enterocolitica subsp. palearctica Y11]
ATGATGAAATGCCCAGTTTGTGGTGGTGCAGAATTAATCCACGAAGCGCGTGACGTCCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGACAACATTGCCCGGCATGCGGTGAAACAATCATGACTGAAGCTGAGTCCGATACCT
ATGCCGCAAAAACAATGCTTTTGCGAAAAATGGTTAATACAGAATCGATTGCACCCGCATATATTGTGCAGGTGCGAAAA
AAATTGGGTCTAAACCAGCGGGAAGCTAGTGAGATTTTTGGCGGTGGAGTGAATGCTTTTTCGCGTTACGAAAAGGGTAA
GGCGTTGCCACACCGATCAACGATAAAATTGTTGCAAGTACTTGATAAATATCCTGAGTTATTGAATGAAATCAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7FJ92

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7IQA2

References