270184

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4673150..4673752 Replicon chromosome
Accession NZ_CP117244
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ATCC 14028

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag PQQ30_RS22710 Protein ID WP_001159630.1
Coordinates 4673441..4673752 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQQ30_RS22705 Protein ID WP_000362050.1
Coordinates 4673150..4673440 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ30_RS22690 (4670643) 4670643..4671545 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
PQQ30_RS22695 (4671542) 4671542..4672177 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PQQ30_RS22700 (4672174) 4672174..4673103 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PQQ30_RS22705 (4673150) 4673150..4673440 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQQ30_RS22710 (4673441) 4673441..4673752 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PQQ30_RS22715 (4673970) 4673970..4674899 + 930 WP_001127703.1 alpha/beta hydrolase -
PQQ30_RS22720 (4674985) 4674985..4675296 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
PQQ30_RS22725 (4675293) 4675293..4675739 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
PQQ30_RS22730 (4675754) 4675754..4676695 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQQ30_RS22735 (4676740) 4676740..4677177 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
PQQ30_RS22740 (4677174) 4677174..4678046 - 873 WP_000921427.1 virulence factor BrkB family protein -
PQQ30_RS22745 (4678040) 4678040..4678639 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T270184 WP_001159630.1 NZ_CP117244:c4673752-4673441 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT270184 WP_000362050.1 NZ_CP117244:c4673440-4673150 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References