270177

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2421641..2422163 Replicon chromosome
Accession NZ_CP117244
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ATCC 14028

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag PQQ30_RS11830 Protein ID WP_000221343.1
Coordinates 2421879..2422163 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag PQQ30_RS11825 Protein ID WP_000885424.1
Coordinates 2421641..2421889 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ30_RS11800 (2416857) 2416857..2418323 + 1467 WP_000987828.1 hypothetical protein -
PQQ30_RS11805 (2419131) 2419131..2419845 + 715 Protein_2308 helix-turn-helix domain-containing protein -
PQQ30_RS11810 (2419901) 2419901..2420809 - 909 WP_010989018.1 hypothetical protein -
PQQ30_RS11815 (2420952) 2420952..2421284 - 333 WP_000253154.1 DUF1493 family protein -
PQQ30_RS11820 (2421274) 2421274..2421489 - 216 WP_000206207.1 hypothetical protein -
PQQ30_RS11825 (2421641) 2421641..2421889 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQQ30_RS11830 (2421879) 2421879..2422163 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQQ30_RS11835 (2422334) 2422334..2422723 + 390 WP_000194089.1 RidA family protein -
PQQ30_RS11840 (2422775) 2422775..2423854 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
PQQ30_RS11845 (2424047) 2424047..2424535 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
PQQ30_RS11850 (2424580) 2424580..2426088 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2416860..2428945 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T270177 WP_000221343.1 NZ_CP117244:2421879-2422163 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT270177 WP_000885424.1 NZ_CP117244:2421641-2421889 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References