Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2579258..2579781 Replicon chromosome
Accession NZ_CP117242
Organism Staphylococcus aureus strain ATCC 14458

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag PQQ25_RS13475 Protein ID WP_000074048.1
Coordinates 2579258..2579524 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag PQQ25_RS13480 Protein ID WP_000587616.1
Coordinates 2579524..2579781 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ25_RS13455 (2574565) 2574565..2575752 - 1188 WP_000026194.1 MFS transporter -
PQQ25_RS13460 (2576148) 2576148..2576924 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
PQQ25_RS13465 (2576917) 2576917..2577579 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
PQQ25_RS13470 (2577827) 2577827..2578903 - 1077 WP_001076671.1 M42 family metallopeptidase -
PQQ25_RS13475 (2579258) 2579258..2579524 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
PQQ25_RS13480 (2579524) 2579524..2579781 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQQ25_RS13485 (2579887) 2579887..2580081 - 195 WP_001790145.1 hypothetical protein -
PQQ25_RS13490 (2580140) 2580140..2580595 + 456 WP_000732082.1 DUF1307 domain-containing protein -
PQQ25_RS13495 (2580763) 2580763..2582340 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
PQQ25_RS13500 (2582535) 2582535..2583284 + 750 WP_000072443.1 CPBP family lipoprotein N-acylation protein LnsB -
PQQ25_RS13505 (2583508) 2583508..2584701 - 1194 WP_000675395.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T270166 WP_000074048.1 NZ_CP117242:c2579524-2579258 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT270166 WP_000587616.1 NZ_CP117242:c2579781-2579524 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References