Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2522406..2522923 Replicon chromosome
Accession NZ_CP117242
Organism Staphylococcus aureus strain ATCC 14458

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag PQQ25_RS13200 Protein ID WP_000113262.1
Coordinates 2522406..2522672 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag PQQ25_RS13205 Protein ID WP_000584499.1
Coordinates 2522672..2522923 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ25_RS13170 (2517832) 2517832..2518368 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
PQQ25_RS13175 (2518601) 2518601..2519425 - 825 WP_000572040.1 formate/nitrite transporter family protein -
PQQ25_RS13180 (2519642) 2519642..2519824 - 183 WP_000230294.1 hypothetical protein -
PQQ25_RS13185 (2519908) 2519908..2520375 - 468 WP_000153344.1 SRPBCC domain-containing protein -
PQQ25_RS13190 (2520561) 2520561..2522111 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
PQQ25_RS13195 (2522300) 2522300..2522371 - 72 Protein_2498 hypothetical protein -
PQQ25_RS13200 (2522406) 2522406..2522672 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
PQQ25_RS13205 (2522672) 2522672..2522923 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQQ25_RS13210 (2523088) 2523088..2523189 - 102 WP_001791744.1 hypothetical protein -
PQQ25_RS13215 (2523196) 2523196..2523795 - 600 WP_000162813.1 DsbA family protein -
PQQ25_RS13220 (2523814) 2523814..2524176 - 363 WP_000819843.1 DUF4467 domain-containing protein -
PQQ25_RS13225 (2524431) 2524431..2525681 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
PQQ25_RS13230 (2525778) 2525778..2526509 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
PQQ25_RS13235 (2526506) 2526506..2527225 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T270164 WP_000113262.1 NZ_CP117242:c2522672-2522406 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT270164 WP_000584499.1 NZ_CP117242:c2522923-2522672 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References