Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2379232..2379749 Replicon chromosome
Accession NZ_CP117238
Organism Staphylococcus aureus strain ATCC 23235

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag PQQ27_RS11950 Protein ID WP_000113265.1
Coordinates 2379232..2379498 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag PQQ27_RS11955 Protein ID WP_000584499.1
Coordinates 2379498..2379749 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ27_RS11920 (PQQ27_11920) 2374660..2375196 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
PQQ27_RS11925 (PQQ27_11925) 2375430..2376254 - 825 WP_000572038.1 formate/nitrite transporter family protein -
PQQ27_RS11930 (PQQ27_11930) 2376471..2376653 - 183 WP_000230292.1 hypothetical protein -
PQQ27_RS11935 (PQQ27_11935) 2376737..2377204 - 468 WP_000153347.1 SRPBCC domain-containing protein -
PQQ27_RS11940 (PQQ27_11940) 2377390..2378937 - 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
PQQ27_RS11945 (PQQ27_11945) 2379126..2379197 - 72 Protein_2275 hypothetical protein -
PQQ27_RS11950 (PQQ27_11950) 2379232..2379498 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
PQQ27_RS11955 (PQQ27_11955) 2379498..2379749 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQQ27_RS11960 (PQQ27_11960) 2379914..2379994 - 81 WP_223197974.1 hypothetical protein -
PQQ27_RS11965 (PQQ27_11965) 2380022..2380621 - 600 WP_000162810.1 DsbA family protein -
PQQ27_RS11970 (PQQ27_11970) 2380640..2381002 - 363 WP_000819843.1 DUF4467 domain-containing protein -
PQQ27_RS11975 (PQQ27_11975) 2381257..2382507 + 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
PQQ27_RS11980 (PQQ27_11980) 2382604..2383335 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
PQQ27_RS11985 (PQQ27_11985) 2383332..2384051 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T270151 WP_000113265.1 NZ_CP117238:c2379498-2379232 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT270151 WP_000584499.1 NZ_CP117238:c2379749-2379498 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References