Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4915442..4916044 Replicon chromosome
Accession NZ_CP117235
Organism Escherichia coli strain ATCC 25922

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag PQQ28_RS24090 Protein ID WP_000897302.1
Coordinates 4915733..4916044 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQQ28_RS24085 Protein ID WP_000356397.1
Coordinates 4915442..4915732 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ28_RS24060 (4911515) 4911515..4912417 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
PQQ28_RS24065 (4912414) 4912414..4913049 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
PQQ28_RS24070 (4913046) 4913046..4913975 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
PQQ28_RS24075 (4914191) 4914191..4914409 - 219 WP_001314326.1 CopG family transcriptional regulator -
PQQ28_RS24080 (4914805) 4914805..4915083 - 279 WP_001296612.1 hypothetical protein -
PQQ28_RS24085 (4915442) 4915442..4915732 - 291 WP_000356397.1 NadS family protein Antitoxin
PQQ28_RS24090 (4915733) 4915733..4916044 - 312 WP_000897302.1 hypothetical protein Toxin
PQQ28_RS24095 (4916274) 4916274..4917182 + 909 WP_001305059.1 alpha/beta hydrolase -
PQQ28_RS24100 (4917246) 4917246..4918187 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
PQQ28_RS24105 (4918232) 4918232..4918669 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
PQQ28_RS24110 (4918666) 4918666..4919538 - 873 WP_000920762.1 virulence factor BrkB family protein -
PQQ28_RS24115 (4919532) 4919532..4920131 - 600 WP_001443191.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T270145 WP_000897302.1 NZ_CP117235:c4916044-4915733 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT270145 WP_000356397.1 NZ_CP117235:c4915732-4915442 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References