Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 1309276..1309821 Replicon chromosome
Accession NC_017564
Organism Yersinia enterocolitica subsp. palearctica Y11

Toxin (Protein)


Gene name yafQ Uniprot ID A0A7T9XU23
Locus tag Y11_RS06030 Protein ID WP_005161463.1
Coordinates 1309276..1309554 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A7T9Y052
Locus tag Y11_RS06035 Protein ID WP_005161466.1
Coordinates 1309561..1309821 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Y11_RS05990 1304637..1305272 + 636 WP_005161446.1 phage baseplate assembly protein V -
Y11_RS05995 1305269..1305625 + 357 WP_005161449.1 GPW/gp25 family protein -
Y11_RS06000 1305625..1306533 + 909 WP_005178623.1 baseplate assembly protein -
Y11_RS06005 1306526..1307068 + 543 WP_005161456.1 phage tail protein I -
Y11_RS06010 1307065..1307346 + 282 WP_005161459.1 phage tail protein -
Y11_RS06015 1307319..1308611 + 1293 WP_014608992.1 phage tail protein -
Y11_RS21600 1308611..1309223 + 613 Protein_1185 tail fiber assembly protein -
Y11_RS06030 1309276..1309554 - 279 WP_005161463.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
Y11_RS06035 1309561..1309821 - 261 WP_005161466.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
Y11_RS23470 1309893..1310060 - 168 WP_005161469.1 hypothetical protein -
Y11_RS06045 1310202..1310408 + 207 WP_005161471.1 hypothetical protein -
Y11_RS06050 1310398..1310718 + 321 WP_005161473.1 hypothetical protein -
Y11_RS23475 1311160..1311336 + 177 WP_005161476.1 hypothetical protein -
Y11_RS06055 1311542..1312426 + 885 WP_072077259.1 Rpn family recombination-promoting nuclease/putative transposase -
Y11_RS23480 1312718..1312856 + 139 Protein_1193 ash family protein -
Y11_RS06065 1313089..1313814 - 726 WP_014608996.1 IS21-like element ISYen2A/ISYen2B family helper ATPase IstB -
Y11_RS06070 1313801..1314556 - 756 Protein_1195 IS21 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - pilW 1300529..1349361 48832


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 11002.70 Da        Isoelectric Point: 9.6243

>T27014 WP_005161463.1 NC_017564:c1309554-1309276 [Yersinia enterocolitica subsp. palearctica Y11]
MTKQREIEYSGQFQKDVKKAQKRHKDINKLKTIMALLIDDKLPLPVIYKDHQLQGNYKGYRDAHIEPDWLIIYKITDDLL
RFERTGSHSDLF

Download         Length: 279 bp

>T27014 NC_017564:c1309554-1309276 [Yersinia enterocolitica subsp. palearctica Y11]
ATGACTAAACAAAGGGAAATTGAATATTCAGGTCAGTTCCAGAAAGATGTGAAAAAAGCTCAGAAGCGCCATAAAGATAT
AAATAAACTTAAAACTATTATGGCGCTGCTAATTGACGATAAATTACCCTTGCCTGTTATATACAAGGATCATCAATTAC
AAGGTAATTACAAAGGTTACAGGGATGCGCATATAGAGCCAGACTGGCTTATCATCTACAAGATTACTGATGATTTGCTT
CGCTTCGAAAGGACAGGAAGCCATTCTGATCTATTTTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9277.75 Da        Isoelectric Point: 7.0134

>AT27014 WP_005161466.1 NC_017564:c1309821-1309561 [Yersinia enterocolitica subsp. palearctica Y11]
MAANAFVRARIDETLKNEAAAVLAGMGLTVSDLVRITLTKVAREKALPFDLRIPNELTAKTIANSEKGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT27014 NC_017564:c1309821-1309561 [Yersinia enterocolitica subsp. palearctica Y11]
ATGGCTGCAAATGCTTTTGTTCGTGCTCGTATAGATGAAACCCTAAAAAATGAAGCCGCTGCTGTGCTTGCTGGCATGGG
TTTAACCGTATCCGATCTGGTGCGGATAACCTTAACCAAGGTCGCCCGAGAAAAAGCGCTTCCGTTCGATTTGCGTATTC
CTAACGAACTTACCGCTAAAACTATTGCCAACAGCGAGAAAGGTGTCGATGTCCACAAAGCAAAGGATGCCGATGATCTG
TTTGATAAATTAGGTATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T9XU23

Antitoxin

Source ID Structure
AlphaFold DB A0A7T9Y052

References