270139

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4033067..4033865 Replicon chromosome
Accession NZ_CP117235
Organism Escherichia coli strain ATCC 25922

Toxin (Protein)


Gene name yeeV Uniprot ID Q8VRA6
Locus tag PQQ28_RS19900 Protein ID WP_000854730.1
Coordinates 4033488..4033865 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P0SQV8
Locus tag PQQ28_RS19895 Protein ID WP_001285481.1
Coordinates 4033067..4033441 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ28_RS19855 (4029042) 4029042..4029494 + 453 WP_000682723.1 hypothetical protein -
PQQ28_RS19860 (4029612) 4029612..4029845 + 234 WP_001213776.1 DUF905 family protein -
PQQ28_RS19865 (4029945) 4029945..4030766 + 822 WP_001234359.1 DUF932 domain-containing protein -
PQQ28_RS19870 (4030766) 4030766..4031011 + 246 WP_001164966.1 hypothetical protein -
PQQ28_RS19875 (4031105) 4031105..4031578 + 474 WP_001313575.1 antirestriction protein -
PQQ28_RS19880 (4031594) 4031594..4032070 + 477 WP_001313574.1 RadC family protein -
PQQ28_RS19885 (4032133) 4032133..4032354 + 222 WP_000692315.1 DUF987 domain-containing protein -
PQQ28_RS19890 (4032373) 4032373..4033017 + 645 WP_000086761.1 hypothetical protein -
PQQ28_RS19895 (4033067) 4033067..4033441 + 375 WP_001285481.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
PQQ28_RS19900 (4033488) 4033488..4033865 + 378 WP_000854730.1 TA system toxin CbtA family protein Toxin
PQQ28_RS19905 (4033862) 4033862..4034354 + 493 Protein_3831 DUF5983 family protein -
PQQ28_RS19910 (4034433) 4034433..4035421 - 989 Protein_3832 IS630 family transposase -
PQQ28_RS19915 (4035569) 4035569..4035757 - 189 Protein_3833 IS66 family transposase -
PQQ28_RS19920 (4035818) 4035818..4036951 + 1134 WP_000555401.1 IS110-like element ISEc45 family transposase -
PQQ28_RS19925 (4037205) 4037205..4038609 - 1405 Protein_3835 IS66 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4033067..4043554 10487
- inside Genomic island - - 3986686..4043554 56868


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14212.21 Da        Isoelectric Point: 7.2923

>T270139 WP_000854730.1 NZ_CP117235:4033488-4033865 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR

Download         Length: 378 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13817.53 Da        Isoelectric Point: 4.7511

>AT270139 WP_001285481.1 NZ_CP117235:4033067-4033441 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTIG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V671

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0SQV8

References