Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1919388..1919890 Replicon chromosome
Accession NZ_CP117235
Organism Escherichia coli strain ATCC 25922

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag PQQ28_RS09470 Protein ID WP_000767822.1
Coordinates 1919636..1919890 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag PQQ28_RS09465 Protein ID WP_001259255.1
Coordinates 1919388..1919639 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ28_RS09440 (1914566) 1914566..1915633 - 1068 WP_000080122.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
PQQ28_RS09445 (1915633) 1915633..1916703 - 1071 WP_000108995.1 histidinol-phosphate transaminase -
PQQ28_RS09450 (1916700) 1916700..1918004 - 1305 WP_001297912.1 histidinol dehydrogenase -
PQQ28_RS09455 (1918010) 1918010..1918909 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
PQQ28_RS09460 (1919055) 1919055..1919105 - 51 WP_001364200.1 his operon leader peptide -
PQQ28_RS09465 (1919388) 1919388..1919639 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
PQQ28_RS09470 (1919636) 1919636..1919890 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
PQQ28_RS09475 (1919973) 1919973..1920797 + 825 WP_000754733.1 SDR family oxidoreductase -
PQQ28_RS09480 (1920843) 1920843..1921772 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
PQQ28_RS09485 (1921987) 1921987..1922049 + 63 WP_010723108.1 membrane protein YoeI -
PQQ28_RS09490 (1922039) 1922039..1923397 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T270128 WP_000767822.1 NZ_CP117235:1919636-1919890 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT270128 WP_001259255.1 NZ_CP117235:1919388-1919639 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References