Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2492067..2492590 Replicon chromosome
Accession NZ_CP117230
Organism Staphylococcus aureus strain ATCC 25923

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2W3LFI1
Locus tag PQQ26_RS12430 Protein ID WP_000074047.1
Coordinates 2492067..2492333 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag PQQ26_RS12435 Protein ID WP_000587617.1
Coordinates 2492333..2492590 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ26_RS12410 (PQQ26_12410) 2487277..2488464 - 1188 WP_000026190.1 MFS transporter -
PQQ26_RS12415 (PQQ26_12415) 2488858..2489634 - 777 WP_000072154.1 iron export ABC transporter permease subunit FetB -
PQQ26_RS12420 (PQQ26_12420) 2489627..2490289 - 663 WP_000923514.1 ATP-binding cassette domain-containing protein -
PQQ26_RS12425 (PQQ26_12425) 2490635..2491711 - 1077 WP_001076679.1 M42 family metallopeptidase -
PQQ26_RS12430 (PQQ26_12430) 2492067..2492333 - 267 WP_000074047.1 Txe/YoeB family addiction module toxin Toxin
PQQ26_RS12435 (PQQ26_12435) 2492333..2492590 - 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQQ26_RS12440 (PQQ26_12440) 2492950..2493405 + 456 WP_000732090.1 YehR family lipoprotein -
PQQ26_RS12445 (PQQ26_12445) 2493573..2495150 - 1578 WP_000143489.1 FMN-binding glutamate synthase family protein -
PQQ26_RS12450 (PQQ26_12450) 2495346..2496095 + 750 WP_000072447.1 CPBP family lipoprotein N-acylation protein LnsB -
PQQ26_RS12455 (PQQ26_12455) 2496319..2497512 - 1194 WP_000675407.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10662.26 Da        Isoelectric Point: 10.1384

>T270122 WP_000074047.1 NZ_CP117230:c2492333-2492067 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRIVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT270122 WP_000587617.1 NZ_CP117230:c2492590-2492333 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W3LFI1

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References