Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2460752..2460936 Replicon chromosome
Accession NZ_CP117230
Organism Staphylococcus aureus strain ATCC 25923

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag PQQ26_RS12290 Protein ID WP_000482647.1
Coordinates 2460829..2460936 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2460752..2460812 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ26_RS12275 (PQQ26_12275) 2456262..2456429 - 168 Protein_2376 hypothetical protein -
PQQ26_RS12280 (PQQ26_12280) 2456660..2458393 - 1734 WP_000486507.1 ABC transporter ATP-binding protein -
PQQ26_RS12285 (PQQ26_12285) 2458418..2460181 - 1764 WP_001064828.1 ATP-binding cassette domain-containing protein -
- 2460752..2460812 + 61 - - Antitoxin
PQQ26_RS12290 (PQQ26_12290) 2460829..2460936 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
PQQ26_RS12295 (PQQ26_12295) 2461070..2461456 - 387 WP_000779351.1 flippase GtxA -
PQQ26_RS12300 (PQQ26_12300) 2461724..2462866 + 1143 WP_001176855.1 glycerate kinase -
PQQ26_RS12305 (PQQ26_12305) 2462926..2463585 + 660 WP_000831298.1 membrane protein -
PQQ26_RS12310 (PQQ26_12310) 2463767..2464978 + 1212 WP_001191919.1 multidrug effflux MFS transporter -
PQQ26_RS12315 (PQQ26_12315) 2465101..2465574 - 474 WP_000456499.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T270121 WP_000482647.1 NZ_CP117230:c2460936-2460829 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

Antitoxin


Download         Length: 61 bp

>AT270121 NZ_CP117230:2460752-2460812 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References