Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2435451..2435968 Replicon chromosome
Accession NZ_CP117230
Organism Staphylococcus aureus strain ATCC 25923

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag PQQ26_RS12155 Protein ID WP_000251928.1
Coordinates 2435451..2435717 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag PQQ26_RS12160 Protein ID WP_000584497.1
Coordinates 2435717..2435968 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ26_RS12130 (PQQ26_12130) 2430659..2431195 - 537 WP_000024292.1 GNAT family N-acetyltransferase -
PQQ26_RS12135 (PQQ26_12135) 2431662..2432486 - 825 WP_000594640.1 formate/nitrite transporter family protein -
PQQ26_RS12140 (PQQ26_12140) 2432689..2432871 - 183 WP_000079140.1 hypothetical protein -
PQQ26_RS12145 (PQQ26_12145) 2432958..2433425 - 468 WP_000153340.1 SRPBCC domain-containing protein -
PQQ26_RS12150 (PQQ26_12150) 2433611..2435158 - 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
PQQ26_RS12155 (PQQ26_12155) 2435451..2435717 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
PQQ26_RS12160 (PQQ26_12160) 2435717..2435968 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQQ26_RS12165 (PQQ26_12165) 2436132..2436232 - 101 Protein_2354 hypothetical protein -
PQQ26_RS12170 (PQQ26_12170) 2436239..2436838 - 600 WP_000162804.1 DsbA family protein -
PQQ26_RS12175 (PQQ26_12175) 2436857..2437219 - 363 WP_000819843.1 DUF4467 domain-containing protein -
PQQ26_RS12180 (PQQ26_12180) 2437474..2438724 + 1251 Protein_2357 FemA/FemB family glycyltransferase FmhA -
PQQ26_RS12185 (PQQ26_12185) 2438821..2439552 - 732 WP_000615465.1 amino acid ABC transporter ATP-binding protein -
PQQ26_RS12190 (PQQ26_12190) 2439549..2440268 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T270120 WP_000251928.1 NZ_CP117230:c2435717-2435451 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT270120 WP_000584497.1 NZ_CP117230:c2435968-2435717 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References