Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2493925..2494448 Replicon chromosome
Accession NZ_CP117203
Organism Staphylococcus aureus strain 2022QW-00133

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag PQQ74_RS12435 Protein ID WP_000074048.1
Coordinates 2493925..2494191 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag PQQ74_RS12440 Protein ID WP_000587616.1
Coordinates 2494191..2494448 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ74_RS12415 (2489232) 2489232..2490419 - 1188 WP_000026194.1 MFS transporter -
PQQ74_RS12420 (2490815) 2490815..2491591 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
PQQ74_RS12425 (2491584) 2491584..2492246 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
PQQ74_RS12430 (2492494) 2492494..2493570 - 1077 WP_273655799.1 M42 family metallopeptidase -
PQQ74_RS12435 (2493925) 2493925..2494191 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
PQQ74_RS12440 (2494191) 2494191..2494448 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQQ74_RS12445 (2494807) 2494807..2495262 + 456 WP_000732082.1 DUF1307 domain-containing protein -
PQQ74_RS12450 (2495430) 2495430..2497007 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
PQQ74_RS12455 (2497202) 2497202..2497951 + 750 WP_050957244.1 CPBP family lipoprotein N-acylation protein LnsB -
PQQ74_RS12460 (2498175) 2498175..2499368 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T270092 WP_000074048.1 NZ_CP117203:c2494191-2493925 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT270092 WP_000587616.1 NZ_CP117203:c2494448-2494191 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References