Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2437077..2437594 Replicon chromosome
Accession NZ_CP117203
Organism Staphylococcus aureus strain 2022QW-00133

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag PQQ74_RS12160 Protein ID WP_000113262.1
Coordinates 2437077..2437343 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag PQQ74_RS12165 Protein ID WP_000584502.1
Coordinates 2437343..2437594 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ74_RS12130 (2432503) 2432503..2433039 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
PQQ74_RS12135 (2433272) 2433272..2434096 - 825 WP_000572040.1 formate/nitrite transporter family protein -
PQQ74_RS12140 (2434313) 2434313..2434495 - 183 WP_000230294.1 hypothetical protein -
PQQ74_RS12145 (2434579) 2434579..2435046 - 468 WP_273655797.1 SRPBCC domain-containing protein -
PQQ74_RS12150 (2435232) 2435232..2436782 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
PQQ74_RS12155 (2436971) 2436971..2437042 - 72 Protein_2348 hypothetical protein -
PQQ74_RS12160 (2437077) 2437077..2437343 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
PQQ74_RS12165 (2437343) 2437343..2437594 - 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQQ74_RS12170 (2437759) 2437759..2437860 - 102 WP_001791744.1 hypothetical protein -
PQQ74_RS12175 (2437867) 2437867..2438466 - 600 WP_000162813.1 DsbA family protein -
PQQ74_RS12180 (2438485) 2438485..2438844 - 360 WP_000819847.1 DUF4467 domain-containing protein -
PQQ74_RS12185 (2439099) 2439099..2440349 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
PQQ74_RS12190 (2440446) 2440446..2441177 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
PQQ74_RS12195 (2441174) 2441174..2441893 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T270090 WP_000113262.1 NZ_CP117203:c2437343-2437077 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT270090 WP_000584502.1 NZ_CP117203:c2437594-2437343 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References