Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF3/-
Location 1996143..1996442 Replicon chromosome
Accession NZ_CP117203
Organism Staphylococcus aureus strain 2022QW-00133

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag PQQ74_RS09775 Protein ID WP_011447039.1
Coordinates 1996266..1996442 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 1996143..1996198 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ74_RS09735 1991474..1991734 + 261 WP_001791826.1 hypothetical protein -
PQQ74_RS09740 1991787..1992137 - 351 WP_000702263.1 complement inhibitor SCIN-A -
PQQ74_RS09745 1992822..1993271 + 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
PQQ74_RS09750 1993366..1993701 - 336 Protein_1881 SH3 domain-containing protein -
PQQ74_RS09755 1994351..1994842 - 492 WP_000919350.1 staphylokinase -
PQQ74_RS09760 1995033..1995788 - 756 WP_000861038.1 CHAP domain-containing protein -
PQQ74_RS09765 1995800..1996054 - 255 WP_000611512.1 phage holin -
PQQ74_RS09770 1996106..1996213 + 108 WP_001791821.1 hypothetical protein -
- 1996135..1996274 + 140 NuclAT_0 - -
- 1996135..1996274 + 140 NuclAT_0 - -
- 1996135..1996274 + 140 NuclAT_0 - -
- 1996135..1996274 + 140 NuclAT_0 - -
- 1996143..1996198 + 56 - - Antitoxin
PQQ74_RS09775 1996266..1996442 - 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
PQQ74_RS09780 1996592..1996888 - 297 WP_000539688.1 DUF2951 domain-containing protein -
PQQ74_RS09785 1996946..1997233 - 288 WP_001040261.1 hypothetical protein -
PQQ74_RS09790 1997280..1997432 - 153 WP_001153681.1 hypothetical protein -
PQQ74_RS09795 1997422..2001207 - 3786 WP_273655515.1 phage tail spike protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / chp / sak / hlb / groEL 1991787..2047736 55949


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T270084 WP_011447039.1 NZ_CP117203:c1996442-1996266 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 56 bp

>AT270084 NZ_CP117203:1996143-1996198 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References