Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3945576..3946260 Replicon chromosome
Accession NZ_CP117199
Organism Pantoea sp. SS70

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PO881_RS18255 Protein ID WP_101762747.1
Coordinates 3945952..3946260 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PO881_RS18250 Protein ID WP_101762746.1
Coordinates 3945576..3945908 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO881_RS18235 (PO881_18235) 3942378..3944057 - 1680 WP_280172180.1 potassium-transporting ATPase subunit KdpA -
PO881_RS18240 (PO881_18240) 3944057..3944146 - 90 WP_081113208.1 K(+)-transporting ATPase subunit F -
PO881_RS18245 (PO881_18245) 3944256..3945419 - 1164 WP_280172181.1 HD-GYP domain-containing protein -
PO881_RS18250 (PO881_18250) 3945576..3945908 - 333 WP_101762746.1 HigA family addiction module antitoxin Antitoxin
PO881_RS18255 (PO881_18255) 3945952..3946260 - 309 WP_101762747.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PO881_RS18260 (PO881_18260) 3946384..3947775 - 1392 WP_280172182.1 MFS transporter -
PO881_RS18265 (PO881_18265) 3948187..3949101 + 915 WP_192415485.1 sugar ABC transporter substrate-binding protein -
PO881_RS18270 (PO881_18270) 3949184..3949678 - 495 WP_280172183.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(7-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-70)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 12123.94 Da        Isoelectric Point: 10.3572

>T270072 WP_101762747.1 NZ_CP117199:c3946260-3945952 [Pantoea sp. SS70]
MKGSIHSFRDDWLRLFFVYATPHKHIPAMIESALARKLDIIHAATSHHDLRSPPGNRFEALRPPLLGYYSIRINEQYRLI
FQWVNGTARDLYLDPHTYRKHR

Download         Length: 309 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12618.41 Da        Isoelectric Point: 5.7065

>AT270072 WP_101762746.1 NZ_CP117199:c3945908-3945576 [Pantoea sp. SS70]
MKQAMRKPTSVGDVLQYEFLEPLNLKVNDLAEMLNVHRNTVSALVNNNRKLTTEMAYRLAAVFDTSVDFWLNLQRHLDLW
EVENDARTQEELSRVTPLSAFLAQRSAVVA

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References