Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1926276..1927008 Replicon chromosome
Accession NZ_CP117196
Organism Pasteurella multocida strain P2237

Toxin (Protein)


Gene name higB Uniprot ID A0A2J9QLH7
Locus tag M9D40_RS09145 Protein ID WP_005725755.1
Coordinates 1926276..1926602 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M9D40_RS09150 Protein ID WP_005757699.1
Coordinates 1926682..1927008 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9D40_RS09125 (M9D40_009125) 1922334..1923863 - 1530 WP_170353002.1 YifB family Mg chelatase-like AAA ATPase -
M9D40_RS09130 (M9D40_009130) 1923971..1924588 - 618 WP_005724253.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
M9D40_RS09135 (M9D40_009135) 1924699..1925568 + 870 WP_170353000.1 VirK/YbjX family protein -
M9D40_RS09140 (M9D40_009140) 1925642..1926118 - 477 WP_170352998.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
M9D40_RS09145 (M9D40_009145) 1926276..1926602 + 327 WP_005725755.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M9D40_RS09150 (M9D40_009150) 1926682..1927008 + 327 WP_005757699.1 HigA family addiction module antitoxin Antitoxin
M9D40_RS09155 (M9D40_009155) 1927063..1928583 - 1521 WP_170352996.1 surface lipoprotein assembly modifier -
M9D40_RS09160 (M9D40_009160) 1928642..1929232 - 591 WP_170353008.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
M9D40_RS09165 (M9D40_009165) 1929295..1930311 - 1017 WP_250012029.1 protein PlpE -
M9D40_RS09170 (M9D40_009170) 1930558..1931589 - 1032 WP_115098071.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(12-104)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-102)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12892.73 Da        Isoelectric Point: 9.6705

>T270062 WP_005725755.1 NZ_CP117196:1926276-1926602 [Pasteurella multocida]
MDRVRFNLTEDSFQDKYLYEYFLYGSKHKNIPSDIENTLAHKLDMLDSANTLSDLRSPPGNKLEKLEPKTSGLYSIRVNV
KYRLIFKYKESNFPKITELRLDKHQYRL

Download         Length: 327 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12377.41 Da        Isoelectric Point: 7.2034

>AT270062 WP_005757699.1 NZ_CP117196:1926682-1927008 [Pasteurella multocida]
MSRVQRKPSTVGDILLDEYLVPLNLKIADLATMLDVHRNTASALVNNNTKLSLEMALKLAKLFNTSPEFWLNLQMKLDLW
EIENNARFQESLKKISSIDQHNLLEKIA

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9QLH7

Antitoxin

Source ID Structure

References