Detailed information of TA system TA270058

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 24308..24734
• Replicon: plasmid p123_CTX-M
• Accession: NZ_CP117185
• Organism: Salmonella enterica subsp. enterica strain 123

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: PQ453_RS24980
• Protein ID: WP_001372321.1
• Coordinates: 24609..24734 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	24308..24532 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PQ453_RS24945 (19406)	19406..19873	-	468	Protein_27	hypothetical protein	-
PQ453_RS24950 (20175)	20175..20702	+	528	WP_000290834.1	single-stranded DNA-binding protein	-
PQ453_RS24955 (20760)	20760..20993	+	234	WP_000006003.1	DUF905 family protein	-
PQ453_RS24960 (21054)	21054..23077	+	2024	Protein_30	ParB/RepB/Spo0J family partition protein	-
PQ453_RS24965 (23146)	23146..23580	+	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
PQ453_RS24970 (23577)	23577..24296	+	720	WP_001276217.1	plasmid SOS inhibition protein A	-
- (24308)	24308..24532	+	225	NuclAT_0	-	Antitoxin
- (24308)	24308..24532	+	225	NuclAT_0	-	Antitoxin
- (24308)	24308..24532	+	225	NuclAT_0	-	Antitoxin
- (24308)	24308..24532	+	225	NuclAT_0	-	Antitoxin
PQ453_RS24975 (24518)	24518..24667	+	150	Protein_33	plasmid maintenance protein Mok	-
PQ453_RS24980 (24609)	24609..24734	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
PQ453_RS24985 (25053)	25053..25349	-	297	Protein_35	hypothetical protein	-
PQ453_RS24990 (25649)	25649..25945	+	297	WP_001272251.1	hypothetical protein	-
PQ453_RS24995 (26056)	26056..26877	+	822	WP_001234445.1	DUF932 domain-containing protein	-
PQ453_RS25000 (27174)	27174..27764	-	591	WP_000252683.1	transglycosylase SLT domain-containing protein	-
PQ453_RS25005 (28099)	28099..28482	+	384	WP_001354030.1	conjugal transfer relaxosome DNA-binding protein TraM	-
PQ453_RS25010 (28676)	28676..29347	+	672	WP_000283561.1	conjugal transfer transcriptional regulator TraJ	-
PQ453_RS25015 (29484)	29484..29711	+	228	WP_000089263.1	conjugal transfer relaxosome protein TraY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T270058 WP_001372321.1 NZ_CP117185:24609-24734 [Salmonella enterica subsp. enterica]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

Antitoxin

Nucleotide

• Length: 225 bp

>AT270058 NZ_CP117185:24308-24532 [Salmonella enterica subsp. enterica]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Structures

Antitoxin