270057

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4988753..4989355 Replicon chromosome
Accession NZ_CP117184
Organism Salmonella enterica subsp. enterica strain 123

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag PQ453_RS24625 Protein ID WP_001159630.1
Coordinates 4988753..4989064 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQ453_RS24630 Protein ID WP_000362050.1
Coordinates 4989065..4989355 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQ453_RS24590 (4983866) 4983866..4984465 + 600 WP_000965695.1 glucose-1-phosphatase -
PQ453_RS24595 (4984459) 4984459..4985331 + 873 WP_000921427.1 virulence factor BrkB family protein -
PQ453_RS24600 (4985328) 4985328..4985765 + 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
PQ453_RS24605 (4985810) 4985810..4986751 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQ453_RS24610 (4986766) 4986766..4987212 - 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
PQ453_RS24615 (4987209) 4987209..4987520 - 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
PQ453_RS24620 (4987606) 4987606..4988535 - 930 WP_001127703.1 alpha/beta hydrolase -
PQ453_RS24625 (4988753) 4988753..4989064 + 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PQ453_RS24630 (4989065) 4989065..4989355 + 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQ453_RS24635 (4989402) 4989402..4990331 - 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PQ453_RS24640 (4990328) 4990328..4990963 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PQ453_RS24645 (4990960) 4990960..4991862 - 903 WP_000331361.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T270057 WP_001159630.1 NZ_CP117184:4988753-4989064 [Salmonella enterica subsp. enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT270057 WP_000362050.1 NZ_CP117184:4989065-4989355 [Salmonella enterica subsp. enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References