Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 2690843..2691537 Replicon chromosome
Accession NC_017554
Organism Pantoea ananatis PA13

Toxin (Protein)


Gene name yafO Uniprot ID -
Locus tag PAGR_RS12665 Protein ID WP_026020955.1
Coordinates 2690843..2691241 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID -
Locus tag PAGR_RS12670 Protein ID WP_014606006.1
Coordinates 2691244..2691537 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAGR_RS12630 2685969..2687060 + 1092 WP_013025517.1 redox-regulated ATPase YchF -
PAGR_RS23525 2687331..2688498 - 1168 Protein_2473 IS3 family transposase -
PAGR_RS12655 2688776..2689606 + 831 WP_014606003.1 hypothetical protein -
PAGR_RS23710 2689800..2690114 - 315 Protein_2475 hypothetical protein -
PAGR_RS12665 2690843..2691241 - 399 WP_026020955.1 type II toxin-antitoxin system YafO family toxin Toxin
PAGR_RS12670 2691244..2691537 - 294 WP_014606006.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
PAGR_RS12675 2691833..2692121 + 289 Protein_2478 hypothetical protein -
PAGR_RS23715 2692151..2692624 + 474 WP_141118332.1 hypothetical protein -
PAGR_RS12680 2692929..2693213 - 285 WP_014606008.1 conjugal transfer protein TraD -
PAGR_RS12685 2693213..2693467 - 255 WP_014606009.1 hypothetical protein -
PAGR_RS12690 2694330..2695718 + 1389 WP_014606010.1 MobA/MobL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2689169..2706229 17060
- flank IS/Tn - - 2688199..2688498 299


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15274.57 Da        Isoelectric Point: 6.9778

>T27004 WP_026020955.1 NC_017554:c2691241-2690843 [Pantoea ananatis PA13]
IRIFKSALIRQQLSQQELDDLAADFLSYKKDGVLPDTFGRDAPYDDDRTYPLVKEEQVAHIHLADADAPFPKFLRQFKRT
SDQAHLVYCQGAMDPDAYLLIIILKPEAHKMARNNNYMHKIGMIAEAFKMKY

Download         Length: 399 bp

>T27004 NC_017554:c2691241-2690843 [Pantoea ananatis PA13]
ATCAGGATTTTCAAGTCAGCACTGATCCGTCAACAATTAAGCCAACAAGAGCTTGATGATTTAGCAGCGGATTTTCTGTC
CTATAAAAAGGATGGCGTGTTGCCAGATACCTTTGGGCGTGATGCGCCTTATGATGATGACCGCACCTATCCCTTGGTAA
AAGAAGAGCAGGTGGCCCACATTCATCTTGCCGATGCGGATGCCCCTTTCCCGAAGTTTTTACGTCAGTTCAAACGAACC
AGCGATCAGGCGCATTTGGTATACTGCCAAGGTGCGATGGATCCCGATGCCTATCTGCTGATTATCATCCTGAAACCTGA
AGCGCATAAAATGGCGCGCAACAATAACTATATGCATAAGATCGGGATGATAGCCGAAGCGTTCAAGATGAAGTATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10998.48 Da        Isoelectric Point: 5.2075

>AT27004 WP_014606006.1 NC_017554:c2691537-2691244 [Pantoea ananatis PA13]
MERILAEKSINITELRKNPAKYFIDEPVAVLSNNRPAGYMVSAKVFEELLDLLEEKQGRVHAAARFRPTAERLSDIADSG
HKLLQNPSDKDLTEFTE

Download         Length: 294 bp

>AT27004 NC_017554:c2691537-2691244 [Pantoea ananatis PA13]
ATGGAACGCATTCTCGCAGAAAAATCTATCAACATCACCGAGTTAAGAAAGAACCCGGCGAAATATTTTATTGATGAACC
GGTTGCCGTTCTTTCCAACAACCGTCCCGCTGGTTACATGGTCAGTGCCAAGGTTTTTGAAGAGCTGCTCGATCTGTTGG
AAGAAAAGCAGGGTCGGGTGCATGCTGCTGCGCGTTTCAGGCCAACGGCTGAACGTTTAAGTGATATTGCGGATAGTGGA
CACAAACTGCTGCAAAACCCCTCTGACAAGGATCTGACCGAGTTCACGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References