Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 3768778..3769505 | Replicon | chromosome |
| Accession | NZ_CP117181 | ||
| Organism | Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F28S | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A418Z4H3 |
| Locus tag | PQP75_RS18230 | Protein ID | WP_017441960.1 |
| Coordinates | 3769194..3769505 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | PQP75_RS18225 | Protein ID | WP_000561389.1 |
| Coordinates | 3768778..3769197 (-) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PQP75_RS18195 (3765598) | 3765598..3766126 | + | 529 | Protein_3533 | transposase | - |
| PQP75_RS18200 (3766272) | 3766272..3766412 | - | 141 | WP_031615664.1 | hypothetical protein | - |
| PQP75_RS18205 (3766578) | 3766578..3766847 | - | 270 | WP_077907250.1 | hypothetical protein | - |
| PQP75_RS18210 (3767218) | 3767218..3767637 | + | 420 | WP_017441959.1 | GNAT family N-acetyltransferase | - |
| PQP75_RS18215 (3767873) | 3767873..3768031 | - | 159 | WP_023165344.1 | lipopolysaccharide 1,2-N-acetylglucosaminetransferase | - |
| PQP75_RS18220 (3768028) | 3768028..3768522 | - | 495 | WP_077907251.1 | glycosyltransferase | - |
| PQP75_RS18225 (3768778) | 3768778..3769197 | - | 420 | WP_000561389.1 | helix-turn-helix domain-containing protein | Antitoxin |
| PQP75_RS18230 (3769194) | 3769194..3769505 | - | 312 | WP_017441960.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| PQP75_RS18235 (3769684) | 3769684..3769983 | + | 300 | WP_017441961.1 | hypothetical protein | - |
| PQP75_RS18240 (3770282) | 3770282..3771064 | - | 783 | WP_023242818.1 | DUF2971 domain-containing protein | - |
| PQP75_RS18245 (3771427) | 3771427..3771579 | - | 153 | WP_153257556.1 | hypothetical protein | - |
| PQP75_RS18250 (3771731) | 3771731..3772207 | - | 477 | WP_017441964.1 | hypothetical protein | - |
| PQP75_RS18255 (3772535) | 3772535..3772930 | - | 396 | WP_000422887.1 | DUF1398 domain-containing protein | - |
| PQP75_RS18260 (3773611) | 3773611..3774333 | + | 723 | WP_017441965.1 | SPI-1 type III secretion system guanine nucleotide exchange factor SopE2 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 3765788..3766126 | 338 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12453.27 Da Isoelectric Point: 10.1599
>T270035 WP_017441960.1 NZ_CP117181:c3769505-3769194 [Salmonella enterica subsp. enterica serovar Mbandaka]
MHVISKEPFDEAARRYPNDSLAIKALYRLVRERDFSSPAELRKVIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFINKRF
YVKHIATHAEYDKLTRYYRENKE
MHVISKEPFDEAARRYPNDSLAIKALYRLVRERDFSSPAELRKVIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFINKRF
YVKHIATHAEYDKLTRYYRENKE
Download Length: 312 bp
Antitoxin
Download Length: 140 a.a. Molecular weight: 15301.49 Da Isoelectric Point: 4.6286
>AT270035 WP_000561389.1 NZ_CP117181:c3769197-3768778 [Salmonella enterica subsp. enterica serovar Mbandaka]
MIANTAKAIEATKALVAAVPFLGGSASEKDYRDALALVDYLIENDDENPLIDFLASKIAEYEDNSKQFAEFNKSVAEMPV
GVALLRTLIDQYKLSYSDLKEEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
MIANTAKAIEATKALVAAVPFLGGSASEKDYRDALALVDYLIENDDENPLIDFLASKIAEYEDNSKQFAEFNKSVAEMPV
GVALLRTLIDQYKLSYSDLKEEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
Download Length: 420 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|