Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 2123550..2124088 Replicon chromosome
Accession NZ_CP117181
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F28S

Toxin (Protein)


Gene name yafQ Uniprot ID M7RHM1
Locus tag PQP75_RS10165 Protein ID WP_001526148.1
Coordinates 2123813..2124088 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A3V4SM47
Locus tag PQP75_RS10160 Protein ID WP_017441598.1
Coordinates 2123550..2123810 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP75_RS10145 (2119303) 2119303..2120856 + 1554 WP_017441601.1 TROVE domain-containing protein -
PQP75_RS10150 (2121204) 2121204..2122418 + 1215 WP_017441600.1 RNA-splicing ligase RtcB -
PQP75_RS10155 (2122422) 2122422..2123441 + 1020 WP_017441599.1 RNA 3'-terminal phosphate cyclase -
PQP75_RS10160 (2123550) 2123550..2123810 + 261 WP_017441598.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PQP75_RS10165 (2123813) 2123813..2124088 + 276 WP_001526148.1 type II toxin-antitoxin system YafQ family toxin Toxin
PQP75_RS10170 (2124176) 2124176..2126881 - 2706 WP_000907030.1 HTH-type transcriptional regulator MalT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10739.34 Da        Isoelectric Point: 8.8652

>T270028 WP_001526148.1 NZ_CP117181:2123813-2124088 [Salmonella enterica subsp. enterica serovar Mbandaka]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIEPDWILIYKITDECLR
FERTGTHADLF

Download         Length: 276 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9460.83 Da        Isoelectric Point: 4.4734

>AT270028 WP_017441598.1 NZ_CP117181:2123550-2123810 [Salmonella enterica subsp. enterica serovar Mbandaka]
MAANALVRARIDETLKDQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGIDIHKAKDADDL
FDQLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SM83

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SM47

References