Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 1582581..1583183 Replicon chromosome
Accession NZ_CP117181
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F28S

Toxin (Protein)


Gene name higB Uniprot ID A0A3V4SQH3
Locus tag PQP75_RS07615 Protein ID WP_001159628.1
Coordinates 1582872..1583183 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQP75_RS07610 Protein ID WP_000362050.1
Coordinates 1582581..1582871 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP75_RS07595 (1580074) 1580074..1580976 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
PQP75_RS07600 (1580973) 1580973..1581608 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PQP75_RS07605 (1581605) 1581605..1582534 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PQP75_RS07610 (1582581) 1582581..1582871 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQP75_RS07615 (1582872) 1582872..1583183 - 312 WP_001159628.1 hypothetical protein Toxin
PQP75_RS07620 (1583401) 1583401..1584330 + 930 WP_017441897.1 alpha/beta hydrolase -
PQP75_RS07625 (1584416) 1584416..1584727 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
PQP75_RS07630 (1584724) 1584724..1585170 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
PQP75_RS07635 (1585185) 1585185..1586126 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQP75_RS07640 (1586171) 1586171..1586608 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
PQP75_RS07645 (1586605) 1586605..1587477 - 873 WP_000921423.1 virulence factor BrkB family protein -
PQP75_RS07650 (1587471) 1587471..1588070 - 600 WP_000965702.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12376.29 Da        Isoelectric Point: 9.4460

>T270024 WP_001159628.1 NZ_CP117181:c1583183-1582872 [Salmonella enterica subsp. enterica serovar Mbandaka]
MQFIETELFTEDVKKLLDDDEYHKFQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT270024 WP_000362050.1 NZ_CP117181:c1582871-1582581 [Salmonella enterica subsp. enterica serovar Mbandaka]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SQH3

Antitoxin

Source ID Structure

References