Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1066175..1066902 Replicon chromosome
Accession NZ_CP117053
Organism Escherichia coli strain MLI106K4

Toxin (Protein)


Gene name higB Uniprot ID A0A829L2T9
Locus tag NL407_RS06335 Protein ID WP_001521139.1
Coordinates 1066175..1066486 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NL407_RS06340 Protein ID WP_000126294.1
Coordinates 1066483..1066902 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL407_RS06310 (1062110) 1062110..1063819 + 1710 WP_001521140.1 formate hydrogenlyase subunit HycE -
NL407_RS06315 (1063829) 1063829..1064371 + 543 WP_000493785.1 formate hydrogenlyase subunit HycF -
NL407_RS06320 (1064371) 1064371..1065138 + 768 WP_000067399.1 formate hydrogenlyase subunit HycG -
NL407_RS06325 (1065135) 1065135..1065545 + 411 WP_001291918.1 formate hydrogenlyase assembly protein HycH -
NL407_RS06330 (1065538) 1065538..1066008 + 471 WP_000132961.1 hydrogenase maturation peptidase HycI -
NL407_RS06335 (1066175) 1066175..1066486 + 312 WP_001521139.1 type II toxin-antitoxin system HigB family toxin Toxin
NL407_RS06340 (1066483) 1066483..1066902 + 420 WP_000126294.1 helix-turn-helix domain-containing protein Antitoxin
NL407_RS06345 (1066981) 1066981..1068405 - 1425 WP_020234028.1 6-phospho-beta-glucosidase AscB -
NL407_RS06350 (1068414) 1068414..1069871 - 1458 WP_020234027.1 PTS cellobiose/arbutin/salicin transporter subunit IIBC -
NL407_RS06355 (1070131) 1070131..1071141 + 1011 WP_015912547.1 DNA-binding transcriptional regulator AscG -
NL407_RS06360 (1071290) 1071290..1071817 + 528 WP_001078777.1 electron transport protein HydN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12493.23 Da        Isoelectric Point: 9.4783

>T269957 WP_001521139.1 NZ_CP117053:1066175-1066486 [Escherichia coli]
MHIISKAPFEECARKYPNDALALYSLYRVIKETDFSTPEEMRTAFPNLDNFRYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15416.42 Da        Isoelectric Point: 4.4596

>AT269957 WP_000126294.1 NZ_CP117053:1066483-1066902 [Escherichia coli]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L2T9

Antitoxin

Source ID Structure

References