Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-rdlD/SymE(toxin)
Location 4228758..4229170 Replicon chromosome
Accession NZ_CP117049
Organism Escherichia coli strain MLI106K2

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag NL423_RS21600 Protein ID WP_000132601.1
Coordinates 4228829..4229170 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 4228758..4228834 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL423_RS21590 (4225621) 4225621..4227210 + 1590 WP_001063200.1 type I restriction-modification system methyltransferase -
NL423_RS21595 (4227207) 4227207..4228601 + 1395 WP_001272445.1 type I restriction-modification system specificity subunit -
- (4228758) 4228758..4228834 - 77 NuclAT_14 - Antitoxin
- (4228758) 4228758..4228834 - 77 NuclAT_14 - Antitoxin
- (4228758) 4228758..4228834 - 77 NuclAT_14 - Antitoxin
- (4228758) 4228758..4228834 - 77 NuclAT_14 - Antitoxin
- (4228758) 4228758..4228834 - 77 NuclAT_15 - Antitoxin
- (4228758) 4228758..4228834 - 77 NuclAT_15 - Antitoxin
- (4228758) 4228758..4228834 - 77 NuclAT_15 - Antitoxin
- (4228758) 4228758..4228834 - 77 NuclAT_15 - Antitoxin
NL423_RS21600 (4228829) 4228829..4229170 + 342 WP_000132601.1 endoribonuclease SymE Toxin
NL423_RS21605 (4229332) 4229332..4230711 + 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
NL423_RS21610 (4230711) 4230711..4231757 + 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T269937 WP_000132601.1 NZ_CP117049:4228829-4229170 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT269937 NZ_CP117049:c4228834-4228758 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References