269925

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1819753..1820255 Replicon chromosome
Accession NZ_CP117049
Organism Escherichia coli strain MLI106K2

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag NL423_RS09845 Protein ID WP_000767829.1
Coordinates 1820001..1820255 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag NL423_RS09840 Protein ID WP_001259255.1
Coordinates 1819753..1820004 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL423_RS09815 (1814930) 1814930..1815997 - 1068 WP_000080090.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
NL423_RS09820 (1815997) 1815997..1817067 - 1071 WP_000108933.1 histidinol-phosphate transaminase -
NL423_RS09825 (1817064) 1817064..1818368 - 1305 WP_001446927.1 histidinol dehydrogenase -
NL423_RS09830 (1818374) 1818374..1819273 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
NL423_RS09835 (1819419) 1819419..1819469 - 51 WP_001364200.1 his operon leader peptide -
NL423_RS09840 (1819753) 1819753..1820004 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
NL423_RS09845 (1820001) 1820001..1820255 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
NL423_RS09850 (1820338) 1820338..1821162 + 825 WP_000754737.1 SDR family oxidoreductase -
NL423_RS09855 (1821208) 1821208..1822137 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
NL423_RS09860 (1822352) 1822352..1822414 + 63 WP_010723108.1 membrane protein YoeI -
NL423_RS09865 (1822404) 1822404..1823762 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
NL423_RS09870 (1823941) 1823941..1824999 + 1059 WP_000492346.1 thiosulfate utilization transporter TsuA/YeeE -
NL423_RS09875 (1825013) 1825013..1825240 + 228 WP_000985272.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T269925 WP_000767829.1 NZ_CP117049:1820001-1820255 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT269925 WP_001259255.1 NZ_CP117049:1819753-1820004 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References