Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 726960..727653 Replicon chromosome
Accession NZ_CP117049
Organism Escherichia coli strain MLI106K2

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag NL423_RS04670 Protein ID WP_000415584.1
Coordinates 726960..727256 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag NL423_RS04675 Protein ID WP_000650107.1
Coordinates 727258..727653 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL423_RS04635 (722048) 722048..722362 - 315 WP_000958598.1 putative quinol monooxygenase -
NL423_RS04640 (722393) 722393..722974 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
NL423_RS04645 (723293) 723293..723625 + 333 WP_023149630.1 DUF2645 family protein -
NL423_RS04650 (723671) 723671..725020 - 1350 WP_001401139.1 quorum sensing histidine kinase QseC -
NL423_RS04655 (725017) 725017..725676 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
NL423_RS04660 (725828) 725828..726220 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
NL423_RS04665 (726273) 726273..726755 + 483 WP_000183505.1 GyrI-like domain-containing protein -
NL423_RS04670 (726960) 726960..727256 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
NL423_RS04675 (727258) 727258..727653 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
NL423_RS04680 (727786) 727786..729393 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
NL423_RS04685 (729531) 729531..731789 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T269921 WP_000415584.1 NZ_CP117049:726960-727256 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT269921 WP_000650107.1 NZ_CP117049:727258-727653 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References