Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2466876..2467398 Replicon chromosome
Accession NZ_CP117033
Organism Salmonella enterica strain PIW95_S14_0299

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag PQP07_RS12150 Protein ID WP_000221343.1
Coordinates 2467114..2467398 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag PQP07_RS12145 Protein ID WP_000885424.1
Coordinates 2466876..2467124 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP07_RS12120 (2462092) 2462092..2463558 + 1467 WP_000987828.1 hypothetical protein -
PQP07_RS12125 (2464366) 2464366..2465080 + 715 Protein_2372 helix-turn-helix domain-containing protein -
PQP07_RS12130 (2465136) 2465136..2466044 - 909 WP_010989018.1 hypothetical protein -
PQP07_RS12135 (2466187) 2466187..2466519 - 333 WP_000253154.1 DUF1493 family protein -
PQP07_RS12140 (2466509) 2466509..2466724 - 216 WP_000206207.1 hypothetical protein -
PQP07_RS12145 (2466876) 2466876..2467124 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQP07_RS12150 (2467114) 2467114..2467398 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP07_RS12155 (2467569) 2467569..2467958 + 390 WP_000194089.1 RidA family protein -
PQP07_RS12160 (2468010) 2468010..2469089 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
PQP07_RS12165 (2469282) 2469282..2469770 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
PQP07_RS12170 (2469815) 2469815..2471323 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2462095..2474180 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T269889 WP_000221343.1 NZ_CP117033:2467114-2467398 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT269889 WP_000885424.1 NZ_CP117033:2466876-2467124 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References