Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 119878..120466 Replicon chromosome
Accession NZ_CP117024
Organism Helicobacter pylori strain 444A6

Toxin (Protein)


Gene name TfiT Uniprot ID J0DAB9
Locus tag PPK11_RS00610 Protein ID WP_000921927.1
Coordinates 120185..120466 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID E8QSE8
Locus tag PPK11_RS00605 Protein ID WP_000065294.1
Coordinates 119878..120192 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PPK11_RS00585 (115429) 115429..116085 + 657 WP_273898057.1 ParA family protein -
PPK11_RS00590 (116168) 116168..116452 + 285 WP_000394651.1 hypothetical protein -
PPK11_RS00595 (116484) 116484..117657 + 1174 Protein_101 hypothetical protein -
PPK11_RS00600 (117682) 117682..119595 - 1914 WP_273898061.1 relaxase/mobilization nuclease domain-containing protein -
PPK11_RS00605 (119878) 119878..120192 + 315 WP_000065294.1 hypothetical protein Antitoxin
PPK11_RS00610 (120185) 120185..120466 + 282 WP_000921927.1 YafQ family addiction module toxin Toxin
PPK11_RS00615 (120717) 120717..122459 - 1743 WP_273898064.1 type IV secretory system conjugative DNA transfer family protein -
PPK11_RS00620 (122460) 122460..123017 - 558 WP_273898066.1 hypothetical protein -
PPK11_RS00625 (123018) 123018..123308 - 291 WP_000159819.1 hypothetical protein -
PPK11_RS00630 (123305) 123305..123760 - 456 WP_108310673.1 mobilization protein -
PPK11_RS00635 (123757) 123757..124698 - 942 WP_154547739.1 ATPase, T2SS/T4P/T4SS family -
PPK11_RS00640 (124698) 124698..124997 - 300 WP_180581140.1 hypothetical protein -
PPK11_RS00645 (124994) 124994..125257 - 264 WP_000564645.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10931.95 Da        Isoelectric Point: 10.1597

>T269873 WP_000921927.1 NZ_CP117024:120185-120466 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRIKESDVTSIVDCLKKQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12166.60 Da        Isoelectric Point: 5.2068

>AT269873 WP_000065294.1 NZ_CP117024:119878-120192 [Helicobacter pylori]
MSNIITDYSQYNEKQLHNFLNSIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTPSLLNTIASKDDPE
YDVSFGDFNDFLQIAKQERERHNA

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060CQM7

Antitoxin

Source ID Structure
AlphaFold DB A0A2T6R0U3

References