Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 1921063..1921790 | Replicon | chromosome |
| Accession | NZ_CP117020 | ||
| Organism | Escherichia coli strain MLI106K3 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | V0YLE2 |
| Locus tag | NL424_RS09665 | Protein ID | WP_000547555.1 |
| Coordinates | 1921479..1921790 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | NL424_RS09660 | Protein ID | WP_000126294.1 |
| Coordinates | 1921063..1921482 (-) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NL424_RS09640 (1916148) | 1916148..1916675 | - | 528 | WP_001078777.1 | electron transport protein HydN | - |
| NL424_RS09645 (1916824) | 1916824..1917834 | - | 1011 | WP_029130985.1 | DNA-binding transcriptional regulator AscG | - |
| NL424_RS09650 (1918094) | 1918094..1919551 | + | 1458 | WP_001107889.1 | PTS cellobiose/arbutin/salicin transporter subunit IIBC | - |
| NL424_RS09655 (1919560) | 1919560..1920984 | + | 1425 | WP_000110355.1 | 6-phospho-beta-glucosidase AscB | - |
| NL424_RS09660 (1921063) | 1921063..1921482 | - | 420 | WP_000126294.1 | helix-turn-helix domain-containing protein | Antitoxin |
| NL424_RS09665 (1921479) | 1921479..1921790 | - | 312 | WP_000547555.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| NL424_RS09670 (1921957) | 1921957..1922427 | - | 471 | WP_000132961.1 | hydrogenase maturation peptidase HycI | - |
| NL424_RS09675 (1922420) | 1922420..1922830 | - | 411 | WP_001291918.1 | formate hydrogenlyase assembly protein HycH | - |
| NL424_RS09680 (1922827) | 1922827..1923594 | - | 768 | WP_000067399.1 | formate hydrogenlyase subunit HycG | - |
| NL424_RS09685 (1923594) | 1923594..1924136 | - | 543 | WP_000493785.1 | formate hydrogenlyase subunit HycF | - |
| NL424_RS09690 (1924146) | 1924146..1925855 | - | 1710 | WP_001288122.1 | formate hydrogenlyase subunit HycE | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12439.18 Da Isoelectric Point: 9.5146
>T269861 WP_000547555.1 NZ_CP117020:c1921790-1921479 [Escherichia coli]
MHIISKAPFEECARKYPNDALALHSLYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE
MHIISKAPFEECARKYPNDALALHSLYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE
Download Length: 312 bp
Antitoxin
Download Length: 140 a.a. Molecular weight: 15416.42 Da Isoelectric Point: 4.4596
>AT269861 WP_000126294.1 NZ_CP117020:c1921482-1921063 [Escherichia coli]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL
Download Length: 420 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|