Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1206653..1207155 Replicon chromosome
Accession NZ_CP117020
Organism Escherichia coli strain MLI106K3

Toxin (Protein)


Gene name yoeB Uniprot ID D3GZ85
Locus tag NL424_RS06380 Protein ID WP_000767820.1
Coordinates 1206653..1206907 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag NL424_RS06385 Protein ID WP_001259255.1
Coordinates 1206904..1207155 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL424_RS06350 (1201668) 1201668..1201895 - 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -
NL424_RS06355 (1201909) 1201909..1202967 - 1059 WP_033547227.1 thiosulfate utilization transporter TsuA/YeeE -
NL424_RS06360 (1203146) 1203146..1204504 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
NL424_RS06365 (1204494) 1204494..1204556 - 63 WP_010723108.1 membrane protein YoeI -
NL424_RS06370 (1204771) 1204771..1205700 - 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
NL424_RS06375 (1205746) 1205746..1206570 - 825 WP_000754756.1 SDR family oxidoreductase -
NL424_RS06380 (1206653) 1206653..1206907 - 255 WP_000767820.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
NL424_RS06385 (1206904) 1206904..1207155 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
NL424_RS06390 (1207438) 1207438..1207488 + 51 WP_001364200.1 his operon leader peptide -
NL424_RS06395 (1207634) 1207634..1208533 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
NL424_RS06400 (1208539) 1208539..1209843 + 1305 WP_085018073.1 histidinol dehydrogenase -
NL424_RS06405 (1209840) 1209840..1210910 + 1071 WP_000108926.1 histidinol-phosphate transaminase -
NL424_RS06410 (1210910) 1210910..1211977 + 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10182.64 Da        Isoelectric Point: 8.0353

>T269860 WP_000767820.1 NZ_CP117020:c1206907-1206653 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKIIELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT269860 WP_001259255.1 NZ_CP117020:c1207155-1206904 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D3GZ85

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References