Detailed information of TA system TA269853

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 339087..339309
• Replicon: chromosome
• Accession: NZ_CP117020
• Organism: Escherichia coli strain MLI106K3

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: D3H2K1
• Locus tag: NL424_RS02050
• Protein ID: WP_000170955.1
• Coordinates: 339087..339194 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	339242..339309 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NL424_RS02020 (334768)	334768..335601	+	834	WP_000456570.1	peptide chain release factor N(5)-glutamine methyltransferase	-
NL424_RS02025 (335598)	335598..335990	+	393	WP_000200377.1	invasion regulator SirB2	-
NL424_RS02030 (335994)	335994..336803	+	810	WP_001257044.1	invasion regulator SirB1	-
NL424_RS02035 (336839)	336839..337693	+	855	WP_085018032.1	3-deoxy-8-phosphooctulonate synthase	-
NL424_RS02040 (337888)	337888..338346	+	459	WP_000526135.1	IS200/IS605-like element IS200C family transposase	-
NL424_RS02045 (338552)	338552..338659	-	108	WP_000176713.1	type I toxin-antitoxin system toxin Ldr family protein	-
- (338707)	338707..338773	+	67	NuclAT_29	-	-
- (338707)	338707..338773	+	67	NuclAT_29	-	-
- (338707)	338707..338773	+	67	NuclAT_29	-	-
- (338707)	338707..338773	+	67	NuclAT_29	-	-
- (338707)	338707..338773	+	67	NuclAT_33	-	-
- (338707)	338707..338773	+	67	NuclAT_33	-	-
- (338707)	338707..338773	+	67	NuclAT_33	-	-
- (338707)	338707..338773	+	67	NuclAT_33	-	-
- (338707)	338707..338773	+	67	NuclAT_37	-	-
- (338707)	338707..338773	+	67	NuclAT_37	-	-
- (338707)	338707..338773	+	67	NuclAT_37	-	-
- (338707)	338707..338773	+	67	NuclAT_37	-	-
- (338707)	338707..338773	+	67	NuclAT_41	-	-
- (338707)	338707..338773	+	67	NuclAT_41	-	-
- (338707)	338707..338773	+	67	NuclAT_41	-	-
- (338707)	338707..338773	+	67	NuclAT_41	-	-
- (338707)	338707..338773	+	67	NuclAT_42	-	-
- (338707)	338707..338773	+	67	NuclAT_42	-	-
- (338707)	338707..338773	+	67	NuclAT_42	-	-
- (338707)	338707..338773	+	67	NuclAT_42	-	-
- (338709)	338709..338774	+	66	NuclAT_11	-	-
- (338709)	338709..338774	+	66	NuclAT_11	-	-
- (338709)	338709..338774	+	66	NuclAT_11	-	-
- (338709)	338709..338774	+	66	NuclAT_11	-	-
- (338709)	338709..338774	+	66	NuclAT_13	-	-
- (338709)	338709..338774	+	66	NuclAT_13	-	-
- (338709)	338709..338774	+	66	NuclAT_13	-	-
- (338709)	338709..338774	+	66	NuclAT_13	-	-
- (338709)	338709..338774	+	66	NuclAT_15	-	-
- (338709)	338709..338774	+	66	NuclAT_15	-	-
- (338709)	338709..338774	+	66	NuclAT_15	-	-
- (338709)	338709..338774	+	66	NuclAT_15	-	-
- (338709)	338709..338774	+	66	NuclAT_17	-	-
- (338709)	338709..338774	+	66	NuclAT_17	-	-
- (338709)	338709..338774	+	66	NuclAT_17	-	-
- (338709)	338709..338774	+	66	NuclAT_17	-	-
- (338709)	338709..338774	+	66	NuclAT_19	-	-
- (338709)	338709..338774	+	66	NuclAT_19	-	-
- (338709)	338709..338774	+	66	NuclAT_19	-	-
- (338709)	338709..338774	+	66	NuclAT_19	-	-
- (338709)	338709..338774	+	66	NuclAT_21	-	-
- (338709)	338709..338774	+	66	NuclAT_21	-	-
- (338709)	338709..338774	+	66	NuclAT_21	-	-
- (338709)	338709..338774	+	66	NuclAT_21	-	-
NL424_RS02050 (339087)	339087..339194	-	108	WP_000170955.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
- (339242)	339242..339309	+	68	NuclAT_10	-	Antitoxin
- (339242)	339242..339309	+	68	NuclAT_10	-	Antitoxin
- (339242)	339242..339309	+	68	NuclAT_10	-	Antitoxin
- (339242)	339242..339309	+	68	NuclAT_10	-	Antitoxin
- (339242)	339242..339309	+	68	NuclAT_12	-	Antitoxin
- (339242)	339242..339309	+	68	NuclAT_12	-	Antitoxin
- (339242)	339242..339309	+	68	NuclAT_12	-	Antitoxin
- (339242)	339242..339309	+	68	NuclAT_12	-	Antitoxin
- (339242)	339242..339309	+	68	NuclAT_14	-	Antitoxin
- (339242)	339242..339309	+	68	NuclAT_14	-	Antitoxin
- (339242)	339242..339309	+	68	NuclAT_14	-	Antitoxin
- (339242)	339242..339309	+	68	NuclAT_14	-	Antitoxin
- (339242)	339242..339309	+	68	NuclAT_16	-	Antitoxin
- (339242)	339242..339309	+	68	NuclAT_16	-	Antitoxin
- (339242)	339242..339309	+	68	NuclAT_16	-	Antitoxin
- (339242)	339242..339309	+	68	NuclAT_16	-	Antitoxin
- (339242)	339242..339309	+	68	NuclAT_18	-	Antitoxin
- (339242)	339242..339309	+	68	NuclAT_18	-	Antitoxin
- (339242)	339242..339309	+	68	NuclAT_18	-	Antitoxin
- (339242)	339242..339309	+	68	NuclAT_18	-	Antitoxin
- (339242)	339242..339309	+	68	NuclAT_20	-	Antitoxin
- (339242)	339242..339309	+	68	NuclAT_20	-	Antitoxin
- (339242)	339242..339309	+	68	NuclAT_20	-	Antitoxin
- (339242)	339242..339309	+	68	NuclAT_20	-	Antitoxin
NL424_RS02055 (339599)	339599..340699	-	1101	WP_001309461.1	sodium-potassium/proton antiporter ChaA	-
NL424_RS02060 (340969)	340969..341199	+	231	WP_001146444.1	putative cation transport regulator ChaB	-
NL424_RS02065 (341357)	341357..342052	+	696	WP_001295621.1	glutathione-specific gamma-glutamylcyclotransferase	-
NL424_RS02070 (342096)	342096..342449	-	354	WP_001169669.1	DsrE/F sulfur relay family protein YchN	-
NL424_RS02075 (342635)	342635..344029	+	1395	WP_001718153.1	inverse autotransporter invasin YchO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	337888..338346	458

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4013.82 Da
• Isoelectric Point: 11.4779

>T269853 WP_000170955.1 NZ_CP117020:c339194-339087 [Escherichia coli]
MTLAQFAMIFWHDLAAPILAGIITAAIVSWWRNRK

Nucleotide

• Length: 108 bp

Antitoxin

Nucleotide

• Length: 68 bp

>AT269853 NZ_CP117020:339242-339309 [Escherichia coli]
GTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCTCT

Structures

Toxin

• AlphaFold DB: A0A829J2A9

Antitoxin