Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4408929..4409187 Replicon chromosome
Accession NZ_CP117013
Organism Escherichia coli strain MLI114

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag NL414_RS21970 Protein ID WP_000809168.1
Coordinates 4409035..4409187 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4408929..4408986 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL414_RS21955 4405321..4406280 + 960 WP_000871682.1 hypothetical protein -
NL414_RS21960 4406318..4407217 - 900 WP_001300855.1 transcriptional activator NhaR -
NL414_RS21965 4407283..4408449 - 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
- 4408929..4408986 - 58 - - Antitoxin
NL414_RS21970 4409035..4409187 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
NL414_RS21975 4409291..4410421 - 1131 WP_001118464.1 molecular chaperone DnaJ -
NL414_RS21980 4410510..4412426 - 1917 WP_000516135.1 molecular chaperone DnaK -
NL414_RS21985 4412802..4413206 + 405 WP_000843579.1 DUF2541 family protein -
NL414_RS21990 4413232..4413945 + 714 WP_001102367.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T269822 WP_000809168.1 NZ_CP117013:4409035-4409187 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT269822 NZ_CP117013:c4408986-4408929 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References