Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 631929..632728 Replicon chromosome
Accession NZ_CP117006
Organism Escherichia coli strain MLI108K3

Toxin (Protein)


Gene name yhaV Uniprot ID F0JQM9
Locus tag NL411_RS04645 Protein ID WP_000347270.1
Coordinates 631929..632393 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A0V9H1L4
Locus tag NL411_RS04650 Protein ID WP_001551693.1
Coordinates 632393..632728 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL411_RS04615 (626930) 626930..627364 - 435 WP_000948837.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NL411_RS04620 (627382) 627382..628260 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NL411_RS04625 (628250) 628250..629029 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
NL411_RS04630 (629040) 629040..629513 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
NL411_RS04635 (629536) 629536..630816 - 1281 WP_001551694.1 tagatose-bisphosphate aldolase subunit KbaZ -
NL411_RS04640 (631065) 631065..631874 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NL411_RS04645 (631929) 631929..632393 - 465 WP_000347270.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NL411_RS04650 (632393) 632393..632728 - 336 WP_001551693.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NL411_RS04655 (632877) 632877..634448 - 1572 WP_001273738.1 galactarate dehydratase -
NL411_RS04660 (634823) 634823..636157 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
NL411_RS04665 (636173) 636173..636943 + 771 WP_072617374.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17806.22 Da        Isoelectric Point: 9.6924

>T269736 WP_000347270.1 NZ_CP117006:c632393-631929 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEEAH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12347.87 Da        Isoelectric Point: 4.6890

>AT269736 WP_001551693.1 NZ_CP117006:c632728-632393 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDTQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NQ90

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9H1L4

References