269716

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1226221..1226723 Replicon chromosome
Accession NZ_CP117001
Organism Escherichia coli strain MLI108K2

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag NL410_RS08095 Protein ID WP_000767829.1
Coordinates 1226221..1226475 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag NL410_RS08100 Protein ID WP_001259255.1
Coordinates 1226472..1226723 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL410_RS08065 (1221236) 1221236..1221463 - 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -
NL410_RS08070 (1221477) 1221477..1222535 - 1059 WP_000492321.1 thiosulfate utilization transporter TsuA/YeeE -
NL410_RS08075 (1222714) 1222714..1224072 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
NL410_RS08080 (1224062) 1224062..1224124 - 63 WP_010723108.1 membrane protein YoeI -
NL410_RS08085 (1224339) 1224339..1225268 - 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
NL410_RS08090 (1225314) 1225314..1226138 - 825 WP_000754749.1 SDR family oxidoreductase -
NL410_RS08095 (1226221) 1226221..1226475 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
NL410_RS08100 (1226472) 1226472..1226723 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
NL410_RS08105 (1227007) 1227007..1227057 + 51 WP_001364200.1 his operon leader peptide -
NL410_RS08110 (1227203) 1227203..1228102 + 900 WP_032329340.1 ATP phosphoribosyltransferase -
NL410_RS08115 (1228108) 1228108..1229412 + 1305 WP_001446927.1 histidinol dehydrogenase -
NL410_RS08120 (1229409) 1229409..1230479 + 1071 WP_000108945.1 histidinol-phosphate transaminase -
NL410_RS08125 (1230479) 1230479..1231546 + 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T269716 WP_000767829.1 NZ_CP117001:c1226475-1226221 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT269716 WP_001259255.1 NZ_CP117001:c1226723-1226472 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References