Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4588336..4588938 Replicon chromosome
Accession NZ_CP116987
Organism Escherichia coli strain MLI107

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag NL408_RS22220 Protein ID WP_000897305.1
Coordinates 4588627..4588938 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NL408_RS22215 Protein ID WP_000356397.1
Coordinates 4588336..4588626 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL408_RS22190 (4584280) 4584280..4585182 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
NL408_RS22195 (4585179) 4585179..4585814 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
NL408_RS22200 (4585811) 4585811..4586740 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
NL408_RS22205 (4587070) 4587070..4587312 - 243 WP_001087409.1 protein YiiF -
NL408_RS22210 (4587532) 4587532..4587750 - 219 WP_001315930.1 CopG family transcriptional regulator -
NL408_RS22215 (4588336) 4588336..4588626 - 291 WP_000356397.1 NadS family protein Antitoxin
NL408_RS22220 (4588627) 4588627..4588938 - 312 WP_000897305.1 hypothetical protein Toxin
NL408_RS22225 (4589167) 4589167..4590075 + 909 WP_001162704.1 alpha/beta hydrolase -
NL408_RS22230 (4590139) 4590139..4591080 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
NL408_RS22235 (4591125) 4591125..4591562 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
NL408_RS22240 (4591559) 4591559..4592431 - 873 WP_000920762.1 virulence factor BrkB family protein -
NL408_RS22245 (4592425) 4592425..4593024 - 600 WP_001295269.1 glucose-1-phosphatase -
NL408_RS22250 (4593123) 4593123..4593908 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T269665 WP_000897305.1 NZ_CP116987:c4588938-4588627 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT269665 WP_000356397.1 NZ_CP116987:c4588626-4588336 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References