Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3747501..3748042 Replicon chromosome
Accession NZ_CP116987
Organism Escherichia coli strain MLI107

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag NL408_RS18355 Protein ID WP_000615976.1
Coordinates 3747764..3748042 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag NL408_RS18350 Protein ID WP_000729704.1
Coordinates 3747501..3747761 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL408_RS18325 (3743284) 3743284..3744069 - 786 WP_000207574.1 putative lateral flagellar export/assembly protein LafU -
NL408_RS18330 (3744041) 3744041..3745753 + 1713 Protein_3587 flagellar biosynthesis protein FlhA -
NL408_RS18335 (3745858) 3745858..3746136 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
NL408_RS18340 (3746129) 3746129..3746485 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
NL408_RS18345 (3746542) 3746542..3747315 - 774 WP_000543897.1 C40 family peptidase -
NL408_RS18350 (3747501) 3747501..3747761 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
NL408_RS18355 (3747764) 3747764..3748042 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
NL408_RS18360 (3748198) 3748198..3748938 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
NL408_RS18365 (3748909) 3748909..3749676 - 768 WP_000333380.1 class II glutamine amidotransferase -
NL408_RS18370 (3749882) 3749882..3750460 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T269661 WP_000615976.1 NZ_CP116987:3747764-3748042 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT269661 WP_000729704.1 NZ_CP116987:3747501-3747761 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References