Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 155097..155351 Replicon plasmid pE6474.1
Accession NZ_CP116982
Organism Escherichia coli strain E6474

Toxin (Protein)


Gene name srnB Uniprot ID G9G1E3
Locus tag PO910_RS23920 Protein ID WP_001312851.1
Coordinates 155202..155351 (+) Length 50 a.a.

Antitoxin (RNA)


Gene name srnC
Locus tag -
Coordinates 155097..155158 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO910_RS23905 (153050) 153050..153793 + 744 WP_039002216.1 conjugal transfer pilus acetylase TraX -
PO910_RS23910 (153848) 153848..154408 + 561 WP_000139310.1 fertility inhibition protein FinO -
PO910_RS23915 (154543) 154543..154755 + 213 WP_001541896.1 ANR family transcriptional regulator -
- (155097) 155097..155158 - 62 NuclAT_1 - Antitoxin
- (155097) 155097..155158 - 62 NuclAT_1 - Antitoxin
- (155097) 155097..155158 - 62 NuclAT_1 - Antitoxin
- (155097) 155097..155158 - 62 NuclAT_1 - Antitoxin
PO910_RS23920 (155202) 155202..155351 + 150 WP_001312851.1 Hok/Gef family protein Toxin
PO910_RS23925 (155619) 155619..155876 + 258 WP_001541895.1 replication regulatory protein RepA -
PO910_RS23930 (155979) 155979..156162 + 184 Protein_175 plasmid copy control protein CopA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(A) / ant(3'')-Ia / cmlA1 / aadA2 / dfrA12 / sul3 - 1..156174 156174


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(4-45)


Sequences

Toxin        


Download         Length: 50 a.a.        Molecular weight: 5542.67 Da        Isoelectric Point: 8.7678

>T269642 WP_001312851.1 NZ_CP116982:155202-155351 [Escherichia coli]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Download         Length: 150 bp

Antitoxin


Download         Length: 62 bp

>AT269642 NZ_CP116982:c155158-155097 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C8K5

Antitoxin

Download structure file

References