Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4725726..4726328 Replicon chromosome
Accession NZ_CP116981
Organism Escherichia coli strain E6474

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag PO910_RS22880 Protein ID WP_000897305.1
Coordinates 4725726..4726037 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PO910_RS22885 Protein ID WP_000356397.1
Coordinates 4726038..4726328 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO910_RS22855 (4721640) 4721640..4722239 + 600 WP_001295269.1 glucose-1-phosphatase -
PO910_RS22860 (4722233) 4722233..4723105 + 873 WP_000920762.1 virulence factor BrkB family protein -
PO910_RS22865 (4723102) 4723102..4723539 + 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
PO910_RS22870 (4723584) 4723584..4724525 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
PO910_RS22875 (4724589) 4724589..4725497 - 909 WP_001162704.1 alpha/beta hydrolase -
PO910_RS22880 (4725726) 4725726..4726037 + 312 WP_000897305.1 hypothetical protein Toxin
PO910_RS22885 (4726038) 4726038..4726328 + 291 WP_000356397.1 NadS family protein Antitoxin
PO910_RS22890 (4726914) 4726914..4727132 + 219 WP_001295676.1 CopG family transcriptional regulator -
PO910_RS22895 (4727351) 4727351..4727593 + 243 WP_001087409.1 protein YiiF -
PO910_RS22900 (4727923) 4727923..4728852 - 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
PO910_RS22905 (4728849) 4728849..4729484 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
PO910_RS22910 (4729481) 4729481..4730383 - 903 WP_272753579.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T269637 WP_000897305.1 NZ_CP116981:4725726-4726037 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT269637 WP_000356397.1 NZ_CP116981:4726038-4726328 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References