Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2740228..2740730 Replicon chromosome
Accession NZ_CP116981
Organism Escherichia coli strain E6474

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag PO910_RS13430 Protein ID WP_001471733.1
Coordinates 2740228..2740482 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag PO910_RS13435 Protein ID WP_001259255.1
Coordinates 2740479..2740730 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO910_RS13410 (2736721) 2736721..2738079 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
PO910_RS13415 (2738069) 2738069..2738131 - 63 WP_010723108.1 membrane protein YoeI -
PO910_RS13420 (2738346) 2738346..2739275 - 930 WP_001374016.1 LysR substrate-binding domain-containing protein -
PO910_RS13425 (2739321) 2739321..2740145 - 825 WP_000754737.1 SDR family oxidoreductase -
PO910_RS13430 (2740228) 2740228..2740482 - 255 WP_001471733.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
PO910_RS13435 (2740479) 2740479..2740730 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
PO910_RS13440 (2741013) 2741013..2741063 + 51 WP_001364200.1 his operon leader peptide -
PO910_RS13445 (2741209) 2741209..2742108 + 900 WP_001374031.1 ATP phosphoribosyltransferase -
PO910_RS13450 (2742114) 2742114..2743418 + 1305 WP_001748534.1 histidinol dehydrogenase -
PO910_RS13455 (2743415) 2743415..2744485 + 1071 WP_001374029.1 histidinol-phosphate transaminase -
PO910_RS13460 (2744485) 2744485..2745552 + 1068 WP_001374028.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10195.64 Da        Isoelectric Point: 8.0353

>T269631 WP_001471733.1 NZ_CP116981:c2740482-2740228 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDIRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT269631 WP_001259255.1 NZ_CP116981:c2740730-2740479 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References