Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 799457..799998 Replicon chromosome
Accession NZ_CP116981
Organism Escherichia coli strain E6474

Toxin (Protein)


Gene name yafQ Uniprot ID E9TC49
Locus tag PO910_RS03785 Protein ID WP_000615982.1
Coordinates 799457..799735 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag PO910_RS03790 Protein ID WP_000729704.1
Coordinates 799738..799998 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO910_RS03770 (797039) 797039..797617 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
PO910_RS03775 (797823) 797823..798590 + 768 WP_000333380.1 class II glutamine amidotransferase -
PO910_RS03780 (798561) 798561..799301 - 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
PO910_RS03785 (799457) 799457..799735 - 279 WP_000615982.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
PO910_RS03790 (799738) 799738..799998 - 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
PO910_RS03795 (800184) 800184..800957 + 774 WP_000543899.1 C40 family peptidase -
PO910_RS03800 (801014) 801014..801370 - 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
PO910_RS03805 (801363) 801363..801641 - 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
PO910_RS03810 (801746) 801746..803839 - 2094 WP_001140806.1 flagellar biosynthesis protein FlhA -
PO910_RS03815 (803823) 803823..804962 - 1140 WP_000785662.1 flagellar type III secretion system protein FlhB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10816.59 Da        Isoelectric Point: 10.0702

>T269615 WP_000615982.1 NZ_CP116981:c799735-799457 [Escherichia coli]
MIQRDIEYSGQFSKDVKVAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT269615 WP_000729704.1 NZ_CP116981:c799998-799738 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References