Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3973839..3974380 Replicon chromosome
Accession NZ_CP116976
Organism Escherichia coli strain CUVM53

Toxin (Protein)


Gene name yafQ Uniprot ID S1FHQ9
Locus tag PQP10_RS19230 Protein ID WP_000615979.1
Coordinates 3973839..3974117 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag PQP10_RS19235 Protein ID WP_000729704.1
Coordinates 3974120..3974380 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP10_RS19215 (3971421) 3971421..3971999 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
PQP10_RS19220 (3972205) 3972205..3972972 + 768 WP_000333379.1 class II glutamine amidotransferase -
PQP10_RS19225 (3972943) 3972943..3973683 - 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
PQP10_RS19230 (3973839) 3973839..3974117 - 279 WP_000615979.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
PQP10_RS19235 (3974120) 3974120..3974380 - 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
PQP10_RS19240 (3974566) 3974566..3975339 + 774 WP_001353765.1 C40 family peptidase -
PQP10_RS19245 (3975515) 3975515..3976012 + 498 WP_000006261.1 REP-associated tyrosine transposase RayT -
PQP10_RS19250 (3976228) 3976228..3977940 - 1713 Protein_3749 flagellar biosynthesis protein FlhA -
PQP10_RS19255 (3977912) 3977912..3978697 + 786 WP_072132640.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - gmhA/lpcA 3961064..3979823 18759


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T269601 WP_000615979.1 NZ_CP116976:c3974117-3973839 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT269601 WP_000729704.1 NZ_CP116976:c3974380-3974120 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1FHQ9

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References