Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3741058..3741751 Replicon chromosome
Accession NZ_CP116976
Organism Escherichia coli strain CUVM53

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag PQP10_RS18125 Protein ID WP_000415584.1
Coordinates 3741058..3741354 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag PQP10_RS18130 Protein ID WP_000650107.1
Coordinates 3741356..3741751 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP10_RS18090 (3736146) 3736146..3736460 - 315 WP_000958598.1 putative quinol monooxygenase -
PQP10_RS18095 (3736491) 3736491..3737072 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
PQP10_RS18100 (3737391) 3737391..3737723 + 333 WP_000917684.1 DUF2645 family protein -
PQP10_RS18105 (3737769) 3737769..3739118 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
PQP10_RS18110 (3739115) 3739115..3739774 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
PQP10_RS18115 (3739926) 3739926..3740318 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
PQP10_RS18120 (3740371) 3740371..3740853 + 483 WP_000183505.1 GyrI-like domain-containing protein -
PQP10_RS18125 (3741058) 3741058..3741354 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
PQP10_RS18130 (3741356) 3741356..3741751 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
PQP10_RS18135 (3741884) 3741884..3743491 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
PQP10_RS18140 (3743629) 3743629..3745887 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T269598 WP_000415584.1 NZ_CP116976:3741058-3741354 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT269598 WP_000650107.1 NZ_CP116976:3741356-3741751 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References